Expression of MOK in cancer - Summary - The Human Protein Atlas

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MOK

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MOK
Gene description	MOK protein kinase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HBF TERT88, NB-4, U-138 MG)
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA027282 , HPA027292
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA027282	HPA027292

GENE INFORMATION
Gene name	MOK (HGNC Symbol)
Synonyms	RAGE, RAGE1, STK30
Description	MOK protein kinase (HGNC Symbol)
Entrez gene summary	This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
Chromosome	14
Cytoband	q32.31
Chromosome location (bp)	102224500 - 102305200
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000080823 (version 83.38)
Entrez gene	5891
UniProt	Q9UQ07 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UQ07
Antibodypedia	MOK antibodies

PROTEIN BROWSER

MOK-001	MOK-003	MOK-007	MOK-008	MOK-009	MOK-010	MOK-020	MOK-028	MOK-030	MOK-033	MOK-034	MOK-040	MOK-041	MOK-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MOK-001 ENSP00000355304 ENST00000361847	Q9UQ07 [Direct mapping] MAPK/MAK/MRK overlapping kinase Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0051726 [regulation of cell cycle] Show all	419 aa 48 kDa	No	0
MOK-003 ENSP00000428942 ENST00000524214	Q9UQ07 [Direct mapping] MAPK/MAK/MRK overlapping kinase Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0051726 [regulation of cell cycle] Show all	389 aa 44.4 kDa	No	0
MOK-007 ENSP00000454098 ENST00000522867	H0YKX6 [Direct mapping] MAPK/MAK/MRK overlapping kinase Show all	Predicted intracellular proteins Show all		95 aa 10.3 kDa	No	0
MOK-008 ENSP00000452978 ENST00000524370	H0YKX6 [Direct mapping] MAPK/MAK/MRK overlapping kinase Show all	Predicted intracellular proteins Show all		95 aa 10.3 kDa	No	0
MOK-009 ENSP00000453224 ENST00000517966	H0YKX6 [Direct mapping] MAPK/MAK/MRK overlapping kinase Show all	Predicted intracellular proteins Show all		95 aa 10.3 kDa	No	0
MOK-010 ENSP00000453762 ENST00000523231	H0YKX6 [Direct mapping] MAPK/MAK/MRK overlapping kinase Show all	Predicted intracellular proteins Show all		95 aa 10.3 kDa	No	0
MOK-020 ENSP00000429469 ENST00000522874	Q9UQ07 [Direct mapping] MAPK/MAK/MRK overlapping kinase Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0051726 [regulation of cell cycle] Show all	418 aa 47.9 kDa	No	0
MOK-028 ENSP00000429672 ENST00000519058	E5RHT7 [Direct mapping] MAPK/MAK/MRK overlapping kinase Show all	Predicted intracellular proteins Show all		125 aa 13.4 kDa	No	0
MOK-030 ENSP00000454203 ENST00000522534	E5RHT7 [Direct mapping] MAPK/MAK/MRK overlapping kinase Show all	Predicted intracellular proteins Show all		125 aa 13.4 kDa	No	0
MOK-033 ENSP00000453799 ENST00000522537	H0YMY9 [Direct mapping] MAPK/MAK/MRK overlapping kinase Show all	Predicted intracellular proteins Show all		96 aa 10.3 kDa	No	0
MOK-034 ENSP00000430416 ENST00000521937	H0YBV8 [Direct mapping] MAPK/MAK/MRK overlapping kinase Show all	Predicted intracellular proteins Show all		113 aa 12.3 kDa	No	0
MOK-040 ENSP00000453950 ENST00000561150	H0YLZ5 [Direct mapping] MAPK/MAK/MRK overlapping kinase Show all	Predicted intracellular proteins Show all		47 aa 5.3 kDa	No	0
MOK-041 ENSP00000453449 ENST00000559838	H0YM36 [Direct mapping] MAPK/MAK/MRK overlapping kinase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	173 aa 19.7 kDa	No	0
MOK-201 ENSP00000193029 ENST00000193029	A0A0A0MQR5 [Direct mapping] MAPK/MAK/MRK overlapping kinase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	418 aa 47.9 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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