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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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HSP90AA1
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

HSP90AA1

Gene description

Heat shock protein 90kDa alpha (cytosolic), class A member 1

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
CAB002058
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable), liver cancer (unfavourable) and breast cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Breast cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB002058

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of malignant tissues were negative. Moderate to strong cytoplasmic immunoreactivity was observed in several testicular- and endometrial cancers.

GENE INFORMATION

Gene name

HSP90AA1 (HGNC Symbol)

Synonyms

FLJ31884, Hsp89, Hsp90, HSP90N, HSPC1, HSPCA

Description

Heat shock protein 90kDa alpha (cytosolic), class A member 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

14

Cytoband

q32.31

Chromosome location (bp)

102080738 - 102139699

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000080824 (version 83.38)

Entrez gene

3320

UniProt

P07900 (UniProt - Evidence at protein level)

neXtProt

NX_P07900

Antibodypedia

HSP90AA1 antibodies

PROTEIN BROWSER

HSP90AA1-001
HSP90AA1-002
HSP90AA1-005
HSP90AA1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HSP90AA1-001
ENSP00000335153
ENST00000334701
P07900 [Direct mapping]
Heat shock protein HSP 90-alpha
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006839 [mitochondrial transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0006950 [response to stress]
GO:0006986 [response to unfolded protein]
GO:0006996 [organelle organization]
GO:0007165 [signal transduction]
GO:0007411 [axon guidance]
GO:0009408 [response to heat]
GO:0009409 [response to cold]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0023026 [MHC class II protein complex binding]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030911 [TPR domain binding]
GO:0032587 [ruffle membrane]
GO:0034605 [cellular response to heat]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042026 [protein refolding]
GO:0042470 [melanosome]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043202 [lysosomal lumen]
GO:0043209 [myelin sheath]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045040 [protein import into mitochondrial outer membrane]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0046209 [nitric oxide metabolic process]
GO:0046677 [response to antibiotic]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051020 [GTPase binding]
GO:0051082 [unfolded protein binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0061684 [chaperone-mediated autophagy]
GO:0070062 [extracellular exosome]
GO:0071682 [endocytic vesicle lumen]
GO:1900034 [regulation of cellular response to heat]
Show all
854 aa
98.2 kDa
No 0
HSP90AA1-002
ENSP00000216281
ENST00000216281
P07900 [Direct mapping]
Heat shock protein HSP 90-alpha
K9JA46 [Target identity:100%; Query identity:100%]
Epididymis luminal secretory protein 52; Heat shock protein 90kDa alpha (Cytosolic), class A member 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006839 [mitochondrial transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0006950 [response to stress]
GO:0006986 [response to unfolded protein]
GO:0006996 [organelle organization]
GO:0007165 [signal transduction]
GO:0007411 [axon guidance]
GO:0009408 [response to heat]
GO:0009409 [response to cold]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0023026 [MHC class II protein complex binding]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030911 [TPR domain binding]
GO:0034605 [cellular response to heat]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042026 [protein refolding]
GO:0042470 [melanosome]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045040 [protein import into mitochondrial outer membrane]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0046209 [nitric oxide metabolic process]
GO:0046677 [response to antibiotic]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051020 [GTPase binding]
GO:0051082 [unfolded protein binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0061684 [chaperone-mediated autophagy]
GO:0070062 [extracellular exosome]
GO:0071682 [endocytic vesicle lumen]
GO:1900034 [regulation of cellular response to heat]
Show all
732 aa
84.7 kDa
No 0
HSP90AA1-005
ENSP00000450712
ENST00000553585
G3V2J8 [Direct mapping]
Heat shock protein HSP 90-alpha
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0051082 [unfolded protein binding]
Show all
174 aa
20.2 kDa
No 0
HSP90AA1-010
ENSP00000489370
ENST00000558600
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
100 aa
11 kDa
No 0

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