Expression of CFHR2 in cancer - Summary - The Human Protein Atlas

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CFHR2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CFHR2
Gene description	Complement factor H-related 2
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct positivity in plasma, extracellular matrix and proximal renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 3 antibodies. HPA038915 , HPA040726 , HPA049813
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038915	HPA040726	HPA049813

GENE INFORMATION
Gene name	CFHR2 (HGNC Symbol)
Synonyms	CFHL2, FHR2, HFL3
Description	Complement factor H-related 2 (HGNC Symbol)
Entrez gene summary	This gene belongs to a family of complement factor H-related genes (CFHR), which are clustered together with complement factor H gene on chromosome 1, and are involved in regulation of complement. Mutations in CFHR genes have been associated with dense deposit disease and atypical haemolytic-uraemic syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015]
Chromosome	1
Cytoband	q31.3
Chromosome location (bp)	196943772 - 196959226
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000080910 (version 83.38)
Entrez gene	3080
UniProt	P36980 (UniProt - Evidence at protein level)
neXtProt	NX_P36980
Antibodypedia	CFHR2 antibodies

PROTEIN BROWSER

CFHR2-001	CFHR2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CFHR2-001 ENSP00000356385 ENST00000367415	P36980 [Direct mapping] Complement factor H-related protein 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] Show all	270 aa 30.7 kDa	Yes	0
CFHR2-005 ENSP00000476677 ENST00000476712	V9GYE7 [Direct mapping] Complement factor H-related protein 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		254 aa 28.9 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.