Cell atlas - CXCL2 - The Human Protein Atlas

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CXCL2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CXCL2
Gene description	Chemokine (C-X-C motif) ligand 2
Protein class	Cancer-related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (BJ hTERT+, U-87 MG, hTCEpi, RPTEC TERT1)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ hTERT+, U-87 MG, hTCEpi, RPTEC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CXCL2 (HGNC Symbol)
Synonyms	CINC-2a, GRO2, GROb, MGSA-b, MIP-2a, SCYB2
Description	Chemokine (C-X-C motif) ligand 2 (HGNC Symbol)
Entrez gene summary	This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	74097035 - 74099293
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000081041 (version 83.38)
Entrez gene	2920
UniProt	P19875 (UniProt - Evidence at protein level)
neXtProt	NX_P19875
Antibodypedia	CXCL2 antibodies

PROTEIN BROWSER

CXCL2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CXCL2-001 ENSP00000427279 ENST00000508487	P19875 [Direct mapping] C-X-C motif chemokine 2 GRO-beta(5-73) A0A024RDD9 [Target identity:100%; Query identity:100%] C-X-C motif chemokine Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0002237 [response to molecule of bacterial origin] GO:0002690 [positive regulation of leukocyte chemotaxis] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008009 [chemokine activity] GO:0032496 [response to lipopolysaccharide] GO:0042127 [regulation of cell proliferation] GO:0045236 [CXCR chemokine receptor binding] GO:0060326 [cell chemotaxis] GO:0070098 [chemokine-mediated signaling pathway] Show all	107 aa 11.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.