Expression of AFP in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	AFP
Gene description	Alpha-fetoprotein
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (liver cancer, testis cancer)
HPA (cell line):	Cell line enriched (Hep G2)
HPA (normal tissue):	Tissue enhanced (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct extra cellular positivity in selected tissues, for examples placenta. Cytoplasmic expression in liver.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 4 antibodies. HPA010607 , HPA023600 , CAB024283 , CAB025339
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (liver cancer, testis cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA010607	HPA023600	CAB024283	CAB025339

GENE INFORMATION
Gene name	AFP (HGNC Symbol)
Synonyms	FETA, HPAFP
Description	Alpha-fetoprotein (HGNC Symbol)
Entrez gene summary	This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	73431138 - 73456174
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000081051 (version 83.38)
Entrez gene	174
UniProt	P02771 (UniProt - Evidence at protein level)
neXtProt	NX_P02771
Antibodypedia	AFP antibodies

PROTEIN BROWSER

AFP-001	AFP-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AFP-001 ENSP00000379138 ENST00000395792	P02771 [Direct mapping] Alpha-fetoprotein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001542 [ovulation from ovarian follicle] GO:0001889 [liver development] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006810 [transport] GO:0010033 [response to organic substance] GO:0019953 [sexual reproduction] GO:0031016 [pancreas development] GO:0031100 [organ regeneration] GO:0042448 [progesterone metabolic process] GO:0046872 [metal ion binding] GO:0060395 [SMAD protein signal transduction] Show all	609 aa 68.7 kDa	Yes	0
AFP-003 ENSP00000226359 ENST00000226359	J3KMX3 [Direct mapping] Alpha-fetoprotein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006810 [transport] Show all	622 aa 70.4 kDa	Yes	0