Expression of IMPG2 in cancer - Summary - The Human Protein Atlas

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IMPG2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IMPG2
Gene description	Interphotoreceptor matrix proteoglycan 2
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (ovarian cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (fallopian tube)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in photoreceptor cells.

ANTIBODY IHC RELIABILITY
Data reliability description	External characterization data supports antibody staining but no internal RNA data available for correlation. Nuclear positivity was viewed as off target and disregarded.
Reliability score	Supported based on 2 antibodies. HPA008779 , HPA015907
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (ovarian cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008779	HPA015907

GENE INFORMATION
Gene name	IMPG2 (HGNC Symbol)
Synonyms	IPM200, RP56
Description	Interphotoreceptor matrix proteoglycan 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene binds chondroitin sulfate and hyaluronan and is a proteoglycan. The encoded protein plays a role in the organization of the interphotoreceptor matrix and may promote the growth and maintenance of the light-sensitive photoreceptor outer segment. Defects in this gene are a cause of retinitis pigmentosa type 56 and maculopathy, IMPG2-related.[provided by RefSeq, Mar 2011]
Chromosome	3
Cytoband	q12.3
Chromosome location (bp)	101222546 - 101320560
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000081148 (version 83.38)
Entrez gene	50939
UniProt	Q9BZV3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZV3
Antibodypedia	IMPG2 antibodies

PROTEIN BROWSER

IMPG2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IMPG2-001 ENSP00000193391 ENST00000193391	Q9BZV3 [Direct mapping] Interphotoreceptor matrix proteoglycan 2 F1T0J3 [Target identity:100%; Query identity:100%] Interphotoreceptor matrix proteoglycan 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007601 [visual perception] GO:0008201 [heparin binding] GO:0016021 [integral component of membrane] GO:0043235 [receptor complex] Show all	1241 aa 138.6 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.