Fields »
ABOUT
HELP
BLOG
ARG2

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 ARG2

Gene description

 Arginase 2

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the mitochondria.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
CAB009435
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the mitochondria.

Main location

 Mitochondria (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB009435 CACO-2 Mitochondria
CAB009435 U-2 OS Nucleoplasm
Mitochondria

GENE INFORMATION

Gene name

 ARG2

Synonyms

Description

 Arginase 2 (HGNC Symbol)

Entrez gene summary

 Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q24.1

Chromosome location (bp)

 67619798 - 67651720

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000081181 (version 83.38)

Entrez gene

 384

UniProt

 P78540 (UniProt - Evidence at protein level)

neXtProt

 NX_P78540

Antibodypedia

 ARG2 antibodies

PROTEIN BROWSER
ARG2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARG2-001
ENSP00000261783
ENST00000261783
P78540 [Direct mapping]
Arginase-2, mitochondrial
A0A024R6A0 [Target identity:100%; Query identity:100%]
Arginase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000050 [urea cycle]
GO:0001657 [ureteric bud development]
GO:0004053 [arginase activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006525 [arginine metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006941 [striated muscle contraction]
GO:0016813 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
Show all
 354 aa
38.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.