Expression of CDC14B in cancer - Summary - The Human Protein Atlas

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CDC14B

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CDC14B
Gene description	Cell division cycle 14B
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Membranous staining was viewed as off target and disregarded.
Reliability score	Approved based on 1 antibody. HPA013312
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and thyroid cancer (unfavourable).
Renal cancer p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA013312

GENE INFORMATION
Gene name	CDC14B (HGNC Symbol)
Synonyms	Cdc14B1, Cdc14B2, CDC14B3, hCDC14B
Description	Cell division cycle 14B (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband
Chromosome location (bp)	96490241 - 96619830
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000081377 (version 83.38)
Entrez gene	8555
UniProt	O60729 (UniProt - Evidence at protein level)
neXtProt	NX_O60729
Antibodypedia	CDC14B antibodies

PROTEIN BROWSER

CDC14B-001	CDC14B-003	CDC14B-004	CDC14B-006	CDC14B-009	CDC14B-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDC14B-001 ENSP00000400480 ENST00000415608	Q5JU07 [Direct mapping] Dual-specificity protein phosphatase CDC14B Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all		228 aa 26.3 kDa	No	0
CDC14B-003 ENSP00000364389 ENST00000375241	O60729 [Direct mapping] Dual specificity protein phosphatase CDC14B Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004722 [protein serine/threonine phosphatase activity] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0031572 [G2 DNA damage checkpoint] GO:0031965 [nuclear membrane] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0051488 [activation of anaphase-promoting complex activity] Show all	498 aa 56.8 kDa	No	0
CDC14B-004 ENSP00000364388 ENST00000375240	O60729 [Direct mapping] Dual specificity protein phosphatase CDC14B Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004722 [protein serine/threonine phosphatase activity] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0031572 [G2 DNA damage checkpoint] GO:0031965 [nuclear membrane] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0051488 [activation of anaphase-promoting complex activity] Show all	459 aa 52.8 kDa	No	0
CDC14B-006 ENSP00000420572 ENST00000463569	O60729 [Direct mapping] Dual specificity protein phosphatase CDC14B Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004722 [protein serine/threonine phosphatase activity] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0031572 [G2 DNA damage checkpoint] GO:0031965 [nuclear membrane] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0051488 [activation of anaphase-promoting complex activity] Show all	485 aa 55.7 kDa	No	1
CDC14B-009 ENSP00000396951 ENST00000452280	H0Y577 [Direct mapping] Dual-specificity protein phosphatase CDC14B Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all		269 aa 31.2 kDa	No	0
CDC14B-010 ENSP00000364390 ENST00000375242	O60729 [Direct mapping] Dual specificity protein phosphatase CDC14B Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004722 [protein serine/threonine phosphatase activity] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0031572 [G2 DNA damage checkpoint] GO:0031965 [nuclear membrane] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0051488 [activation of anaphase-promoting complex activity] Show all	461 aa 52.3 kDa	No	0

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