Expression of IL12RB2 in cancer - Summary - The Human Protein Atlas

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IL12RB2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IL12RB2
Gene description	Interleukin 12 receptor, beta 2
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (melanoma)
HPA (cell line):	Group enriched (HMC-1, SCLC-21H, SK-MEL-30, THP-1)
HPA (normal tissue):	Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA024168
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA024168

GENE INFORMATION
Gene name	IL12RB2
Synonyms
Description	Interleukin 12 receptor, beta 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
Chromosome	1
Cytoband	p31.3
Chromosome location (bp)	67307364 - 67396900
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000081985 (version 83.38)
Entrez gene	3595
UniProt	Q99665 (UniProt - Evidence at protein level)
neXtProt	NX_Q99665
Antibodypedia	IL12RB2 antibodies

PROTEIN BROWSER

IL12RB2-001	IL12RB2-002	IL12RB2-004	IL12RB2-201	IL12RB2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL12RB2-001 ENSP00000262345 ENST00000262345	Q99665 [Direct mapping] Interleukin-12 receptor subunit beta-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0009897 [external side of plasma membrane] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0032496 [response to lipopolysaccharide] GO:0032609 [interferon-gamma production] GO:0032729 [positive regulation of interferon-gamma production] GO:0034097 [response to cytokine] Show all	862 aa 97.1 kDa	Yes	1
IL12RB2-002 ENSP00000400959 ENST00000441640	H0Y5V0 [Direct mapping] Interleukin-12 receptor subunit beta-2 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	230 aa 26.8 kDa	No	0
IL12RB2-004 ENSP00000360039 ENST00000371000	Q99665 [Direct mapping] Interleukin-12 receptor subunit beta-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0032729 [positive regulation of interferon-gamma production] Show all	659 aa 74.6 kDa	Yes	1
IL12RB2-201 ENSP00000445276 ENST00000541374	A0A0A0MTN7 [Direct mapping] Interleukin-12 receptor subunit beta-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	635 aa 71.7 kDa	Yes	0
IL12RB2-202 ENSP00000442443 ENST00000544434	Q99665 [Direct mapping] Interleukin-12 receptor subunit beta-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0032729 [positive regulation of interferon-gamma production] Show all	776 aa 87.5 kDa	Yes	1

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The Human Protein Atlas

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