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ME2

GENERAL INFORMATION

Gene name

 ME2

Gene description

 Malic enzyme 2, NAD(+)-dependent, mitochondrial

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression at variable levels in all cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA008247 , HPA008880
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008247
HPA008880

GENE INFORMATION

Gene name

 ME2

Synonyms

Description

 Malic enzyme 2, NAD(+)-dependent, mitochondrial (HGNC Symbol)

Entrez gene summary

 This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009]

Chromosome

 18

Cytoband

 q21.2

Chromosome location (bp)

 50879049 - 50954257

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000082212 (version 83.38)

Entrez gene

 4200

UniProt

 P23368 (UniProt - Evidence at protein level)

neXtProt

 NX_P23368

Antibodypedia

 ME2 antibodies

PROTEIN BROWSER
ME2-001
ME2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ME2-001
ENSP00000321070
ENST00000321341
P23368 [Direct mapping]
NAD-dependent malic enzyme, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004470 [malic enzyme activity]
GO:0004471 [malate dehydrogenase (decarboxylating) (NAD+) activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006108 [malate metabolic process]
GO:0008948 [oxaloacetate decarboxylase activity]
GO:0009055 [electron carrier activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046872 [metal ion binding]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:1902031 [regulation of NADP metabolic process]
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 584 aa
65.4 kDa 		No 0
ME2-002
ENSP00000372384
ENST00000382927
P23368 [Direct mapping]
NAD-dependent malic enzyme, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004470 [malic enzyme activity]
GO:0004471 [malate dehydrogenase (decarboxylating) (NAD+) activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006108 [malate metabolic process]
GO:0008948 [oxaloacetate decarboxylase activity]
GO:0009055 [electron carrier activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046872 [metal ion binding]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:1902031 [regulation of NADP metabolic process]
Show all
 479 aa
53.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.