Expression of C5orf22 in cancer - Summary - The Human Protein Atlas

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C5orf22

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C5orf22
Gene description	Chromosome 5 open reading frame 22
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA043062
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043062

GENE INFORMATION
Gene name	C5orf22 (HGNC Symbol)
Synonyms	FLJ11193
Description	Chromosome 5 open reading frame 22 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	p13.3
Chromosome location (bp)	31532266 - 31555058
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000082213 (version 83.38)
Entrez gene	55322
UniProt	Q49AR2 (UniProt - Evidence at protein level)
neXtProt	NX_Q49AR2
Antibodypedia	C5orf22 antibodies

PROTEIN BROWSER

C5orf22-001	C5orf22-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C5orf22-001 ENSP00000326879 ENST00000325366	Q49AR2 [Direct mapping] UPF0489 protein C5orf22 A0A024RE14 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		442 aa 50 kDa	No	0
C5orf22-006 ENSP00000430860 ENST00000507818	E5RHP8 [Direct mapping] UPF0489 protein C5orf22 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		156 aa 17.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.