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CCNT2

GENERAL INFORMATION

Gene name

 CCNT2

Gene description

 Cyclin T2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA005559
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), prostate cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001
Prostate cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005559

GENE INFORMATION

Gene name

 CCNT2

Synonyms

Description

 Cyclin T2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

Chromosome

 2

Cytoband

 q21.3

Chromosome location (bp)

 134918235 - 134959342

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000082258 (version 83.38)

Entrez gene

 905

UniProt

 O60583 (UniProt - Evidence at protein level)

neXtProt

 NX_O60583

Antibodypedia

 CCNT2 antibodies

PROTEIN BROWSER
CCNT2-001
CCNT2-002
CCNT2-005
CCNT2-007
CCNT2-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCNT2-001
ENSP00000264157
ENST00000264157
O60583 [Direct mapping]
Cyclin-T2
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000307 [cyclin-dependent protein kinase holoenzyme complex]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0007049 [cell cycle]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity]
GO:0019901 [protein kinase binding]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051301 [cell division]
GO:1901409 [positive regulation of phosphorylation of RNA polymerase II C-terminal domain]
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 730 aa
81 kDa 		No 0
CCNT2-002
ENSP00000295238
ENST00000295238
O60583 [Direct mapping]
Cyclin-T2
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000307 [cyclin-dependent protein kinase holoenzyme complex]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0007049 [cell cycle]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity]
GO:0019901 [protein kinase binding]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051301 [cell division]
GO:1901409 [positive regulation of phosphorylation of RNA polymerase II C-terminal domain]
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 663 aa
73.7 kDa 		No 0
CCNT2-005
ENSP00000415120
ENST00000438691
H7C411 [Direct mapping]
Cyclin-T2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0019901 [protein kinase binding]
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 67 aa
8 kDa 		No 0
CCNT2-007
ENSP00000399497
ENST00000446247
C9JUL2 [Direct mapping]
Cyclin-T2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0019901 [protein kinase binding]
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 131 aa
15 kDa 		No 0
CCNT2-010
ENSP00000387436
ENST00000452521
H7BZ27 [Direct mapping]
Cyclin-T2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0019901 [protein kinase binding]
Show all
 149 aa
17 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.