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DLG3

GENERAL INFORMATION

Gene name

 DLG3

Gene description

 Discs, large homolog 3 (Drosophila)

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in neuronal cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Approved based on 1 antibody.
HPA001733
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and breast cancer (unfavourable).
Renal cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001733

GENE INFORMATION

Gene name

 DLG3 (HGNC Symbol)

Synonyms

 KIAA1232, MRX90, NE-Dlg, NEDLG, PPP1R82, SAP-102, SAP102

Description

 Discs, large homolog 3 (Drosophila) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

Chromosome

 X

Cytoband

 q13.1

Chromosome location (bp)

 70444861 - 70505490

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000082458 (version 83.38)

Entrez gene

 1741

UniProt

 Q92796 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92796

Antibodypedia

 DLG3 antibodies

PROTEIN BROWSER
DLG3-001
DLG3-002
DLG3-003
DLG3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DLG3-001
ENSP00000363480
ENST00000374360
Q92796 [Direct mapping]
Disks large homolog 3
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001736 [establishment of planar polarity]
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0010923 [negative regulation of phosphatase activity]
GO:0014069 [postsynaptic density]
GO:0016323 [basolateral plasma membrane]
GO:0019900 [kinase binding]
GO:0019902 [phosphatase binding]
GO:0019903 [protein phosphatase binding]
GO:0019904 [protein domain specific binding]
GO:0030165 [PDZ domain binding]
GO:0030426 [growth cone]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032281 [AMPA glutamate receptor complex]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043025 [neuronal cell body]
GO:0043113 [receptor clustering]
GO:0043198 [dendritic shaft]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0097120 [receptor localization to synapse]
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 817 aa
90.3 kDa 		No 0
DLG3-002
ENSP00000363475
ENST00000374355
Q92796 [Direct mapping]
Disks large homolog 3
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008285 [negative regulation of cell proliferation]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0010923 [negative regulation of phosphatase activity]
GO:0014069 [postsynaptic density]
GO:0016323 [basolateral plasma membrane]
GO:0019900 [kinase binding]
GO:0019902 [phosphatase binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045211 [postsynaptic membrane]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0097120 [receptor localization to synapse]
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 512 aa
57.9 kDa 		No 0
DLG3-003
ENSP00000194900
ENST00000194900
Q5JUW8 [Direct mapping]
Discs, large homolog 3 (Neuroendocrine-dlg, Drosophila), isoform CRA_b; Disks large homolog 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0016323 [basolateral plasma membrane]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045211 [postsynaptic membrane]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0097120 [receptor localization to synapse]
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 849 aa
93.6 kDa 		No 0
DLG3-201
ENSP00000441393
ENST00000542398
Q92796 [Direct mapping]
Disks large homolog 3
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008285 [negative regulation of cell proliferation]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0010923 [negative regulation of phosphatase activity]
GO:0014069 [postsynaptic density]
GO:0016323 [basolateral plasma membrane]
GO:0019900 [kinase binding]
GO:0019902 [phosphatase binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045211 [postsynaptic membrane]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0097120 [receptor localization to synapse]
Show all
 366 aa
42.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.