Expression of MRPL22 in cancer - Summary - The Human Protein Atlas

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MRPL22

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MRPL22
Gene description	Mitochondrial ribosomal protein L22
Protein class	Predicted intracellular proteins Predicted secreted proteins Ribosomal proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA047063
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047063

GENE INFORMATION
Gene name	MRPL22 (HGNC Symbol)
Synonyms	HSPC158, MRP-L25, RPML25
Description	Mitochondrial ribosomal protein L22 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q33.2
Chromosome location (bp)	154941070 - 154969411
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000082515 (version 83.38)
Entrez gene	29093
UniProt	Q9NWU5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NWU5
Antibodypedia	MRPL22 antibodies

PROTEIN BROWSER

MRPL22-001	MRPL22-002	MRPL22-003	MRPL22-005	MRPL22-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPL22-001 ENSP00000431040 ENST00000523037	Q9NWU5 [Direct mapping] 39S ribosomal protein L22, mitochondrial Show all	Ribosomal proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	206 aa 23.6 kDa	No	0
MRPL22-002 ENSP00000265229 ENST00000265229	Q9NWU5 [Direct mapping] 39S ribosomal protein L22, mitochondrial Show all	Ribosomal proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	126 aa 14.5 kDa	No	0
MRPL22-003 ENSP00000429039 ENST00000522038	E7ESL0 [Direct mapping] 39S ribosomal protein L22, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015934 [large ribosomal subunit] Show all	212 aa 24.3 kDa	Yes	0
MRPL22-005 ENSP00000411177 ENST00000439747	J3KQY1 [Direct mapping] 39S ribosomal protein L22, mitochondrial Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015934 [large ribosomal subunit] Show all	232 aa 26.5 kDa	No	0
MRPL22-201 ENSP00000481879 ENST00000614620	A0A0C4DGX2 [Direct mapping] 39S ribosomal protein L22, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015934 [large ribosomal subunit] Show all	228 aa 26.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.