Cell atlas - ERC1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ERC1
Gene description	ELKS/RAB6-interacting/CAST family member 1
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the plasma membrane & vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Additional location	In addition localized to the Vesicles (supported), Plasma membrane (supported)
Mouse	Localized to the Cytosol in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 3 antibodies. HPA019513 , HPA019523 , HPA024130
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the plasma membrane & vesicles.

Main location

Cytosol (supported)

Additional location

Vesicles (supported), Plasma membrane (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA019513	A-431	Vesicles
HPA019513	A-431	Cytosol
HPA019513	U-2 OS	Vesicles
		Plasma membrane
		Cytosol
HPA019513	U-251 MG	Vesicles
		Plasma membrane
		Cytosol
HPA019523	A-431	Plasma membrane
HPA019523	A-431	Cytosol
HPA019523	U-2 OS	Plasma membrane
HPA019523	U-2 OS	Cytosol
HPA019523	U-251 MG	Plasma membrane
HPA019523	U-251 MG	Cytosol
HPA024130	A-431	Nucleoplasm
HPA024130	A-431	Vesicles
HPA024130	U-2 OS	Cytosol
HPA024130	U-251 MG	Cytosol

MOUSE CELLS

Main location

Cytosol

Additional location

Nuclear bodies

Mouse gene

ENSMUSG00000030172 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA019513	NIH 3T3	Golgi apparatus
HPA019513	NIH 3T3	Cytosol
HPA024130	NIH 3T3	Nuclear bodies
HPA024130	NIH 3T3	Cytosol

GENE INFORMATION
Gene name	ERC1 (HGNC Symbol)
Synonyms	CAST2, ELKS, KIAA1081, MGC12974, RAB6IP2
Description	ELKS/RAB6-interacting/CAST family member 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	12
Cytoband	p13.33
Chromosome location (bp)	990509 - 1495933
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000082805 (version 83.38)
Entrez gene	23085
UniProt	Q8IUD2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IUD2
Antibodypedia	ERC1 antibodies

PROTEIN BROWSER

ERC1-001	ERC1-005	ERC1-006	ERC1-011	ERC1-014	ERC1-015	ERC1-020	ERC1-023	ERC1-201	ERC1-202	ERC1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ERC1-001 ENSP00000438546 ENST00000543086	Q8IUD2 [Direct mapping] ELKS/Rab6-interacting/CAST family member 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0007252 [I-kappaB phosphorylation] GO:0007275 [multicellular organismal development] GO:0008385 [IkappaB kinase complex] GO:0015031 [protein transport] GO:0017137 [Rab GTPase binding] GO:0030165 [PDZ domain binding] GO:0042147 [retrograde transport, endosome to Golgi] GO:0042734 [presynaptic membrane] GO:0043522 [leucine zipper domain binding] GO:0045202 [synapse] GO:0048786 [presynaptic active zone] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	1088 aa 124.9 kDa	No	0
ERC1-005 ENSP00000465628 ENST00000545318	K7EKH8 [Direct mapping] ELKS/Rab6-interacting/CAST family member 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		90 aa 9.3 kDa	No	0
ERC1-006 ENSP00000467476 ENST00000592048	K7EPP6 [Direct mapping] ELKS/Rab6-interacting/CAST family member 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0048786 [presynaptic active zone] Show all	344 aa 40.6 kDa	No	0
ERC1-011 ENSP00000347621 ENST00000355446	G8JLD3 [Direct mapping] ELKS/Rab6-interacting/CAST family member 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0048786 [presynaptic active zone] Show all	1086 aa 124.8 kDa	No	0
ERC1-014 ENSP00000354158 ENST00000360905	Q8IUD2 [Direct mapping] ELKS/Rab6-interacting/CAST family member 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0007252 [I-kappaB phosphorylation] GO:0007275 [multicellular organismal development] GO:0008385 [IkappaB kinase complex] GO:0015031 [protein transport] GO:0017137 [Rab GTPase binding] GO:0030165 [PDZ domain binding] GO:0042147 [retrograde transport, endosome to Golgi] GO:0042734 [presynaptic membrane] GO:0043522 [leucine zipper domain binding] GO:0045202 [synapse] GO:0048786 [presynaptic active zone] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	1116 aa 128.1 kDa	No	0
ERC1-015 ENSP00000442739 ENST00000546231	X6RLX0 [Direct mapping] ELKS/Rab6-interacting/CAST family member 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0048786 [presynaptic active zone] Show all	1120 aa 128.5 kDa	No	0
ERC1-020 ENSP00000467196 ENST00000539802	K7EP25 [Direct mapping] ELKS/Rab6-interacting/CAST family member 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		89 aa 10.1 kDa	No	0
ERC1-023 ENSP00000464959 ENST00000589132	K7EIZ7 [Direct mapping] ELKS/Rab6-interacting/CAST family member 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		145 aa 14.9 kDa	No	0
ERC1-201 ENSP00000380386 ENST00000397203	Q8IUD2 [Direct mapping] ELKS/Rab6-interacting/CAST family member 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0007252 [I-kappaB phosphorylation] GO:0007275 [multicellular organismal development] GO:0008385 [IkappaB kinase complex] GO:0015031 [protein transport] GO:0017137 [Rab GTPase binding] GO:0030165 [PDZ domain binding] GO:0042147 [retrograde transport, endosome to Golgi] GO:0042734 [presynaptic membrane] GO:0043522 [leucine zipper domain binding] GO:0045202 [synapse] GO:0048786 [presynaptic active zone] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	1088 aa 124.9 kDa	No	0
ERC1-202 ENSP00000468263 ENST00000589028	Q8IUD2 [Direct mapping] ELKS/Rab6-interacting/CAST family member 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0007252 [I-kappaB phosphorylation] GO:0007275 [multicellular organismal development] GO:0008385 [IkappaB kinase complex] GO:0015031 [protein transport] GO:0017137 [Rab GTPase binding] GO:0030165 [PDZ domain binding] GO:0042147 [retrograde transport, endosome to Golgi] GO:0042734 [presynaptic membrane] GO:0043522 [leucine zipper domain binding] GO:0045202 [synapse] GO:0048786 [presynaptic active zone] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	1116 aa 128.1 kDa	No	0
ERC1-203 ENSP00000479523 ENST00000611180	Q8IUD2 [Direct mapping] ELKS/Rab6-interacting/CAST family member 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0007252 [I-kappaB phosphorylation] GO:0007275 [multicellular organismal development] GO:0008385 [IkappaB kinase complex] GO:0015031 [protein transport] GO:0017137 [Rab GTPase binding] GO:0030165 [PDZ domain binding] GO:0042147 [retrograde transport, endosome to Golgi] GO:0042734 [presynaptic membrane] GO:0043522 [leucine zipper domain binding] GO:0045202 [synapse] GO:0048786 [presynaptic active zone] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	720 aa 82 kDa	No	0