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XPO1

GENERAL INFORMATION

Gene name

 XPO1

Gene description

 Exportin 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA042933 , CAB010184
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA042933
CAB010184

GENE INFORMATION

Gene name

 XPO1 (HGNC Symbol)

Synonyms

 CRM1, emb

Description

 Exportin 1 (HGNC Symbol)

Entrez gene summary

 This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]

Chromosome

 2

Cytoband

 p15

Chromosome location (bp)

 61477849 - 61538626

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000082898 (version 83.38)

Entrez gene

 7514

UniProt

 O14980 (UniProt - Evidence at protein level)

neXtProt

 NX_O14980

Antibodypedia

 XPO1 antibodies

PROTEIN BROWSER
XPO1-001
XPO1-004
XPO1-006
XPO1-008
XPO1-009
XPO1-015
XPO1-016
XPO1-017
XPO1-018
XPO1-019

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
XPO1-001
ENSP00000384863
ENST00000401558
O14980 [Direct mapping]
Exportin-1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000055 [ribosomal large subunit export from nucleus]
GO:0000056 [ribosomal small subunit export from nucleus]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0003723 [RNA binding]
GO:0005215 [transporter activity]
GO:0005487 [nucleocytoplasmic transporter activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005642 [annulate lamellae]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006611 [protein export from nucleus]
GO:0006886 [intracellular protein transport]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008536 [Ran GTPase binding]
GO:0008565 [protein transporter activity]
GO:0010467 [gene expression]
GO:0010824 [regulation of centrosome duplication]
GO:0015030 [Cajal body]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019904 [protein domain specific binding]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030529 [ribonucleoprotein complex]
GO:0031965 [nuclear membrane]
GO:0034504 [protein localization to nucleus]
GO:0042176 [regulation of protein catabolic process]
GO:0042493 [response to drug]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043488 [regulation of mRNA stability]
GO:0046825 [regulation of protein export from nucleus]
GO:0051028 [mRNA transport]
GO:0075733 [intracellular transport of virus]
Show all
 1071 aa
123.4 kDa 		No 0
XPO1-004
ENSP00000385559
ENST00000406957
O14980 [Direct mapping]
Exportin-1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000055 [ribosomal large subunit export from nucleus]
GO:0000056 [ribosomal small subunit export from nucleus]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0003723 [RNA binding]
GO:0005215 [transporter activity]
GO:0005487 [nucleocytoplasmic transporter activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005642 [annulate lamellae]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006611 [protein export from nucleus]
GO:0006886 [intracellular protein transport]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008536 [Ran GTPase binding]
GO:0010467 [gene expression]
GO:0015030 [Cajal body]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030529 [ribonucleoprotein complex]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043488 [regulation of mRNA stability]
GO:0051028 [mRNA transport]
GO:0075733 [intracellular transport of virus]
Show all
 1071 aa
123.4 kDa 		No 0
XPO1-006
ENSP00000385942
ENST00000404992
O14980 [Direct mapping]
Exportin-1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000055 [ribosomal large subunit export from nucleus]
GO:0000056 [ribosomal small subunit export from nucleus]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0003723 [RNA binding]
GO:0005215 [transporter activity]
GO:0005487 [nucleocytoplasmic transporter activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005642 [annulate lamellae]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006611 [protein export from nucleus]
GO:0006886 [intracellular protein transport]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008536 [Ran GTPase binding]
GO:0010467 [gene expression]
GO:0015030 [Cajal body]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030529 [ribonucleoprotein complex]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043488 [regulation of mRNA stability]
GO:0051028 [mRNA transport]
GO:0075733 [intracellular transport of virus]
Show all
 1071 aa
123.4 kDa 		No 0
XPO1-008
ENSP00000406428
ENST00000443240
C9J673 [Direct mapping]
Exportin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]
Show all
 132 aa
15.2 kDa 		No 0
XPO1-009
ENSP00000390843
ENST00000436018
C9JF49 [Direct mapping]
Exportin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 59 aa
6.7 kDa 		No 0
XPO1-015
ENSP00000413853
ENST00000451765
C9JKM9 [Direct mapping]
Exportin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]
Show all
 179 aa
20.6 kDa 		No 0
XPO1-016
ENSP00000406819
ENST00000449444
C9IYM2 [Direct mapping]
Exportin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 62 aa
7.1 kDa 		No 0
XPO1-017
ENSP00000394951
ENST00000457483
C9IZS4 [Direct mapping]
Exportin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]
Show all
 94 aa
11 kDa 		No 0
XPO1-018
ENSP00000408190
ENST00000422552
C9JQ02 [Direct mapping]
Exportin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]
Show all
 95 aa
11.1 kDa 		No 0
XPO1-019
ENSP00000393484
ENST00000420673
C9JV99 [Direct mapping]
Exportin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]
Show all
 100 aa
11.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.