Tissue expression of TRPM3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TRPM3
Gene description	Transient receptor potential cation channel, subfamily M, member 3
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	14
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (kidney)
GTEx:	Tissue enhanced (cerebellum)
FANTOM5:	Group enriched (cerebellum, retina)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (kidney)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebellum, retina)

GENE INFORMATION
Gene name	TRPM3 (HGNC Symbol)
Synonyms	GON-2, KIAA1616, LTRPC3
Description	Transient receptor potential cation channel, subfamily M, member 3 (HGNC Symbol)
Entrez gene summary	The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband
Chromosome location (bp)	70529063 - 71446904
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000083067 (version 83.38)
Entrez gene	80036
UniProt	Q9HCF6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9HCF6
Antibodypedia	TRPM3 antibodies

PROTEIN BROWSER

TRPM3-002	TRPM3-005	TRPM3-006	TRPM3-007	TRPM3-008	TRPM3-009	TRPM3-010	TRPM3-011	TRPM3-012	TRPM3-014	TRPM3-015	TRPM3-016	TRPM3-201	TRPM3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRPM3-002 ENSP00000379579 ENST00000396283	Q4VXD4 [Direct mapping] Transient receptor potential cation channel subfamily M member 3 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005227 [calcium activated cation channel activity] GO:0016021 [integral component of membrane] GO:0016048 [detection of temperature stimulus] GO:0050951 [sensory perception of temperature stimulus] GO:0098655 [cation transmembrane transport] Show all	275 aa 30.4 kDa	No	0
TRPM3-005 ENSP00000355395 ENST00000361823	Q9HCF6 [Direct mapping] Transient receptor potential cation channel subfamily M member 3 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005227 [calcium activated cation channel activity] GO:0005261 [cation channel activity] GO:0005262 [calcium channel activity] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0016021 [integral component of membrane] GO:0016048 [detection of temperature stimulus] GO:0034220 [ion transmembrane transport] GO:0050951 [sensory perception of temperature stimulus] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	230 aa 25.2 kDa	No	0
TRPM3-006 ENSP00000366301 ENST00000377097	H0Y3D4 [Direct mapping] Transient receptor potential cation channel subfamily M member 3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005261 [cation channel activity] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0071482 [cellular response to light stimulus] GO:0098655 [cation transmembrane transport] Show all	123 aa 13.6 kDa	No	0
TRPM3-007 ENSP00000366315 ENST00000377111	Q9HCF6 [Direct mapping] Transient receptor potential cation channel subfamily M member 3 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005227 [calcium activated cation channel activity] GO:0005261 [cation channel activity] GO:0005262 [calcium channel activity] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016048 [detection of temperature stimulus] GO:0034220 [ion transmembrane transport] GO:0050951 [sensory perception of temperature stimulus] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	1325 aa 152.7 kDa	No	8
TRPM3-008 ENSP00000366314 ENST00000377110	Q9HCF6 [Direct mapping] Transient receptor potential cation channel subfamily M member 3 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005227 [calcium activated cation channel activity] GO:0005261 [cation channel activity] GO:0005262 [calcium channel activity] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016048 [detection of temperature stimulus] GO:0034220 [ion transmembrane transport] GO:0050951 [sensory perception of temperature stimulus] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	1707 aa 194.7 kDa	No	8
TRPM3-009 ENSP00000379581 ENST00000396285	A2A3F3 [Direct mapping] Transient receptor potential cation channel subfamily M member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005227 [calcium activated cation channel activity] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016048 [detection of temperature stimulus] GO:0050951 [sensory perception of temperature stimulus] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	1566 aa 178.7 kDa	No	7
TRPM3-010 ENSP00000366305 ENST00000377101	Q504Y1 [Direct mapping] TRPM3 protein; Transient receptor potential cation channel subfamily M member 3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005227 [calcium activated cation channel activity] GO:0016021 [integral component of membrane] GO:0016048 [detection of temperature stimulus] GO:0050951 [sensory perception of temperature stimulus] GO:0098655 [cation transmembrane transport] Show all	323 aa 35.6 kDa	No	0
TRPM3-011 ENSP00000379587 ENST00000396292	E9PBI7 [Direct mapping] Transient receptor potential cation channel subfamily M member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005227 [calcium activated cation channel activity] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016048 [detection of temperature stimulus] GO:0050951 [sensory perception of temperature stimulus] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	1579 aa 180.2 kDa	No	7
TRPM3-012 ENSP00000379576 ENST00000396280	H7BYP1 [Direct mapping] Transient receptor potential cation channel subfamily M member 3; Transient receptor potential cation channel, subfamily M, member 3, isoform CRA_c Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005227 [calcium activated cation channel activity] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016048 [detection of temperature stimulus] GO:0050951 [sensory perception of temperature stimulus] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	1556 aa 177.8 kDa	No	7
TRPM3-014 ENSP00000350140 ENST00000357533	A2A3F7 [Direct mapping] Transient receptor potential cation channel subfamily M member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005227 [calcium activated cation channel activity] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016048 [detection of temperature stimulus] GO:0050951 [sensory perception of temperature stimulus] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	1711 aa 195.3 kDa	No	7
TRPM3-015 ENSP00000350791 ENST00000358082	A2A3F4 [Direct mapping] Transient receptor potential cation channel subfamily M member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005227 [calcium activated cation channel activity] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016048 [detection of temperature stimulus] GO:0050951 [sensory perception of temperature stimulus] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	1569 aa 179.1 kDa	No	7
TRPM3-016 ENSP00000386127 ENST00000408909	G5E9G1 [Direct mapping] Transient receptor potential cation channel subfamily M member 3; Transient receptor potential cation channel, subfamily M, member 3, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005227 [calcium activated cation channel activity] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016048 [detection of temperature stimulus] GO:0050951 [sensory perception of temperature stimulus] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	1566 aa 178.9 kDa	No	7
TRPM3-201 ENSP00000354066 ENST00000360823	A2A3F4 [Direct mapping] Transient receptor potential cation channel subfamily M member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005227 [calcium activated cation channel activity] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016048 [detection of temperature stimulus] GO:0050951 [sensory perception of temperature stimulus] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	1569 aa 179.1 kDa	No	7
TRPM3-202 ENSP00000366309 ENST00000377105	G5E9G1 [Direct mapping] Transient receptor potential cation channel subfamily M member 3; Transient receptor potential cation channel, subfamily M, member 3, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005227 [calcium activated cation channel activity] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016048 [detection of temperature stimulus] GO:0050951 [sensory perception of temperature stimulus] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	1566 aa 178.9 kDa	No	7