Tissue expression of PALB2 - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PALB2

TISSUE

premium

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PALB2
Gene description	Partner and localizer of BRCA2
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General nuclear membrane and cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. CAB014895
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PALB2 (HGNC Symbol)
Synonyms	FANCN, FLJ21816
Description	Partner and localizer of BRCA2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p12.2
Chromosome location (bp)	23603160 - 23641310
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000083093 (version 83.38)
Entrez gene	79728
UniProt	Q86YC2 (UniProt - Evidence at protein level)
neXtProt	NX_Q86YC2
Antibodypedia	PALB2 antibodies

PROTEIN BROWSER

PALB2-001	PALB2-002	PALB2-005	PALB2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PALB2-001 ENSP00000261584 ENST00000261584	Q86YC2 [Direct mapping] Partner and localizer of BRCA2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0001701 [in utero embryonic development] GO:0001756 [somitogenesis] GO:0001833 [inner cell mass cell proliferation] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0007498 [mesoderm development] GO:0009887 [organ morphogenesis] GO:0031052 [chromosome breakage] GO:0035264 [multicellular organism growth] GO:0036342 [post-anal tail morphogenesis] GO:0043066 [negative regulation of apoptotic process] GO:0045003 [double-strand break repair via synthesis-dependent strand annealing] GO:0048568 [embryonic organ development] Show all	1186 aa 131.3 kDa	No	0
PALB2-002 ENSP00000454703 ENST00000568219	H3BN63 [Direct mapping] Partner and localizer of BRCA2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	891 aa 98 kDa	No	0
PALB2-005 ENSP00000459237 ENST00000566069	I3L1Z5 [Direct mapping] Partner and localizer of BRCA2 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		43 aa 4.8 kDa	No	0
PALB2-006 ENSP00000460666 ENST00000561514	I3L3R6 [Direct mapping] Partner and localizer of BRCA2 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		90 aa 10.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.