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KAT6A

GENERAL INFORMATION

Gene name

 KAT6A

Gene description

 K(lysine) acetyltransferase 6A

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA063266 , HPA065052
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA063266
HPA065052

GENE INFORMATION

Gene name

 KAT6A (HGNC Symbol)

Synonyms

 MOZ, MYST3, RUNXBP2, ZC2HC6A, ZNF220

Description

 K(lysine) acetyltransferase 6A (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with autosomal dominant mental retardation-32. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Chromosome

 8

Cytoband

 p11.21

Chromosome location (bp)

 41929479 - 42051990

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000083168 (version 83.38)

Entrez gene

 7994

UniProt

 Q92794 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92794

Antibodypedia

 KAT6A antibodies

PROTEIN BROWSER
KAT6A-001
KAT6A-002
KAT6A-003
KAT6A-004
KAT6A-005
KAT6A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KAT6A-001
ENSP00000265713
ENST00000265713
Q92794 [Direct mapping]
Histone acetyltransferase KAT6A
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0006323 [DNA packaging]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006473 [protein acetylation]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016605 [PML body]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0030099 [myeloid cell differentiation]
GO:0043966 [histone H3 acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
GO:0090398 [cellular senescence]
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 2004 aa
225 kDa 		No 0
KAT6A-002
ENSP00000430606
ENST00000485568
A5PLL3 [Direct mapping]
Histone acetyltransferase
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006334 [nucleosome assembly]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0043966 [histone H3 acetylation]
GO:0048513 [organ development]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
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 815 aa
93.2 kDa 		No 0
KAT6A-003
ENSP00000399638
ENST00000418721
C9K0F9 [Direct mapping]
Histone acetyltransferase
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0043966 [histone H3 acetylation]
GO:0048513 [organ development]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
Show all
 728 aa
84.1 kDa 		No 0
KAT6A-004
ENSP00000385888
ENST00000406337
Q92794 [Direct mapping]
Histone acetyltransferase KAT6A
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0006323 [DNA packaging]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006473 [protein acetylation]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016605 [PML body]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0030099 [myeloid cell differentiation]
GO:0043966 [histone H3 acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
GO:0090398 [cellular senescence]
Show all
 2004 aa
225 kDa 		No 0
KAT6A-005
ENSP00000396699
ENST00000426524
C9JJY6 [Direct mapping]
Histone acetyltransferase KAT6A
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 13 aa
1.6 kDa 		No 0
KAT6A-201
ENSP00000380136
ENST00000396930
Q92794 [Direct mapping]
Histone acetyltransferase KAT6A
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000786 [nucleosome]
GO:0003007 [heart morphogenesis]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0006323 [DNA packaging]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006473 [protein acetylation]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016605 [PML body]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0030099 [myeloid cell differentiation]
GO:0035019 [somatic stem cell population maintenance]
GO:0035162 [embryonic hemopoiesis]
GO:0035909 [aorta morphogenesis]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043966 [histone H3 acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0060325 [face morphogenesis]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
GO:0090398 [cellular senescence]
Show all
 2004 aa
225 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.