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P2RX5

GENERAL INFORMATION

Gene name

 P2RX5

Gene description

 Purinergic receptor P2X, ligand gated ion channel, 5

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (Daudi, RPMI-8226, U-698)
HPA (normal tissue):Group enriched (appendix, lymph node, spleen, tonsil)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct cytoplasmic expression in subsets of immune cells

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA021948
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021948

GENE INFORMATION

Gene name

 P2RX5 (HGNC Symbol)

Synonyms

 LRH-1, P2X5

Description

 Purinergic receptor P2X, ligand gated ion channel, 5 (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3 (Tax1 binding protein 3). [provided by RefSeq, Mar 2011]

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 3672199 - 3696404

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000083454 (version 83.38)

Entrez gene

 5026

UniProt

 Q93086 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q93086

Antibodypedia

 P2RX5 antibodies

PROTEIN BROWSER
P2RX5-001
P2RX5-004
P2RX5-005
P2RX5-006
P2RX5-007
P2RX5-008
P2RX5-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
P2RX5-001
ENSP00000225328
ENST00000225328
Q93086 [Direct mapping]
P2X purinoceptor 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0001614 [purinergic nucleotide receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004931 [extracellular ATP-gated cation channel activity]
GO:0005216 [ion channel activity]
GO:0005524 [ATP binding]
GO:0005639 [integral component of nuclear inner membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006812 [cation transport]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0035590 [purinergic nucleotide receptor signaling pathway]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0098655 [cation transmembrane transport]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 422 aa
47.2 kDa 		No 1
P2RX5-004
ENSP00000342161
ENST00000345901
Q93086 [Direct mapping]
P2X purinoceptor 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0001614 [purinergic nucleotide receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004931 [extracellular ATP-gated cation channel activity]
GO:0005216 [ion channel activity]
GO:0005524 [ATP binding]
GO:0005639 [integral component of nuclear inner membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006812 [cation transport]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0035590 [purinergic nucleotide receptor signaling pathway]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0098655 [cation transmembrane transport]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 398 aa
44.5 kDa 		No 1
P2RX5-005
ENSP00000448355
ENST00000547178
Q93086 [Direct mapping]
P2X purinoceptor 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0001614 [purinergic nucleotide receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004931 [extracellular ATP-gated cation channel activity]
GO:0005216 [ion channel activity]
GO:0005524 [ATP binding]
GO:0005639 [integral component of nuclear inner membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006812 [cation transport]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0035590 [purinergic nucleotide receptor signaling pathway]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0098655 [cation transmembrane transport]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 421 aa
47.1 kDa 		No 1
P2RX5-006
ENSP00000447545
ENST00000551178
Q93086 [Direct mapping]
P2X purinoceptor 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0001614 [purinergic nucleotide receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004931 [extracellular ATP-gated cation channel activity]
GO:0005216 [ion channel activity]
GO:0005524 [ATP binding]
GO:0005639 [integral component of nuclear inner membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006812 [cation transport]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0035590 [purinergic nucleotide receptor signaling pathway]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0098655 [cation transmembrane transport]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 397 aa
44.4 kDa 		No 1
P2RX5-007
ENSP00000450006
ENST00000552050
B4DEG2 [Direct mapping]
P2X purinoceptor
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0001614 [purinergic nucleotide receptor activity]
GO:0004931 [extracellular ATP-gated cation channel activity]
GO:0005524 [ATP binding]
GO:0005639 [integral component of nuclear inner membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006812 [cation transport]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0035590 [purinergic nucleotide receptor signaling pathway]
GO:0098655 [cation transmembrane transport]
Show all
 362 aa
40.6 kDa 		No 0
P2RX5-008
ENSP00000449495
ENST00000552723
H0YII8 [Direct mapping]
P2X purinoceptor 5
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0001614 [purinergic nucleotide receptor activity]
GO:0004931 [extracellular ATP-gated cation channel activity]
GO:0005524 [ATP binding]
GO:0005639 [integral component of nuclear inner membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006812 [cation transport]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0035590 [purinergic nucleotide receptor signaling pathway]
GO:0098655 [cation transmembrane transport]
Show all
 287 aa
31.8 kDa 		No 0
P2RX5-012
ENSP00000467707
ENST00000552276
K7EQ78 [Direct mapping]
P2X purinoceptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0001614 [purinergic nucleotide receptor activity]
GO:0004931 [extracellular ATP-gated cation channel activity]
GO:0005524 [ATP binding]
GO:0005639 [integral component of nuclear inner membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006812 [cation transport]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0035590 [purinergic nucleotide receptor signaling pathway]
GO:0098655 [cation transmembrane transport]
Show all
 431 aa
48.2 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.