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RRAGB

GENERAL INFORMATION

Gene name

 RRAGB

Gene description

 Ras-related GTP binding B

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA003734
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable), glioma (favourable) and colorectal cancer (unfavourable).
Lung cancer p<0.001
Glioma p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003734

GENE INFORMATION

Gene name

 RRAGB

Synonyms

Description

 Ras-related GTP binding B (HGNC Symbol)

Entrez gene summary

 Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p11.21

Chromosome location (bp)

 55717739 - 55758774

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000083750 (version 83.38)

Entrez gene

 10325

UniProt

 Q5VZM2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5VZM2

Antibodypedia

 RRAGB antibodies

PROTEIN BROWSER
RRAGB-001
RRAGB-002
RRAGB-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RRAGB-001
ENSP00000262850
ENST00000262850
Q5VZM2 [Direct mapping]
Ras-related GTP-binding protein B
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007050 [cell cycle arrest]
GO:0008286 [insulin receptor signaling pathway]
GO:0009267 [cellular response to starvation]
GO:0010467 [gene expression]
GO:0010506 [regulation of autophagy]
GO:0016236 [macroautophagy]
GO:0032006 [regulation of TOR signaling]
GO:0032008 [positive regulation of TOR signaling]
GO:0032561 [guanyl ribonucleotide binding]
GO:0034198 [cellular response to amino acid starvation]
GO:0034448 [EGO complex]
GO:0034613 [cellular protein localization]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0071230 [cellular response to amino acid stimulus]
GO:1990131 [Gtr1-Gtr2 GTPase complex]
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 374 aa
43.3 kDa 		No 0
RRAGB-002
ENSP00000364077
ENST00000374941
Q5VZM2 [Direct mapping]
Ras-related GTP-binding protein B
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007050 [cell cycle arrest]
GO:0008286 [insulin receptor signaling pathway]
GO:0009267 [cellular response to starvation]
GO:0010467 [gene expression]
GO:0010506 [regulation of autophagy]
GO:0016236 [macroautophagy]
GO:0032006 [regulation of TOR signaling]
GO:0032008 [positive regulation of TOR signaling]
GO:0032561 [guanyl ribonucleotide binding]
GO:0034198 [cellular response to amino acid starvation]
GO:0034448 [EGO complex]
GO:0034613 [cellular protein localization]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0071230 [cellular response to amino acid stimulus]
GO:1990131 [Gtr1-Gtr2 GTPase complex]
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 346 aa
40.2 kDa 		No 0
RRAGB-005
ENSP00000410630
ENST00000414239
Q5VZM0 [Direct mapping]
Ras-related GTP-binding protein B
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Predicted intracellular proteins
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005794 [Golgi apparatus]
GO:0009267 [cellular response to starvation]
GO:0010506 [regulation of autophagy]
GO:0034448 [EGO complex]
GO:0043231 [intracellular membrane-bounded organelle]
GO:1990131 [Gtr1-Gtr2 GTPase complex]
Show all
 194 aa
22.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.