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CYLD

GENERAL INFORMATION

Gene name

 CYLD

Gene description

 Cylindromatosis (turban tumor syndrome)

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with most abundant staining in Purkinje cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA050095 , CAB011713
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA050095
CAB011713

GENE INFORMATION

Gene name

 CYLD (HGNC Symbol)

Synonyms

 CYLD1, KIAA0849, USPL2

Description

 Cylindromatosis (turban tumor syndrome) (HGNC Symbol)

Entrez gene summary

 This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q12.1

Chromosome location (bp)

 50742050 - 50801935

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000083799 (version 83.38)

Entrez gene

 1540

UniProt

 Q9NQC7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NQC7

Antibodypedia

 CYLD antibodies

PROTEIN BROWSER
«
CYLD-001
CYLD-002
CYLD-003
CYLD-005
CYLD-006
CYLD-007
CYLD-009
CYLD-010
CYLD-011
CYLD-012
CYLD-014
CYLD-015
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYLD-001
ENSP00000457576
ENST00000569418
Q9NQC7 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase CYLD
A0A024R6T1 [Target identity:100%; Query identity:100%]
Cylindromatosis (Turban tumor syndrome), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005881 [cytoplasmic microtubule]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007049 [cell cycle]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008270 [zinc ion binding]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016055 [Wnt signaling pathway]
GO:0016579 [protein deubiquitination]
GO:0019901 [protein kinase binding]
GO:0030496 [midbody]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032480 [negative regulation of type I interferon production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0036064 [ciliary basal body]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0042347 [negative regulation of NF-kappaB import into nucleus]
GO:0045087 [innate immune response]
GO:0048471 [perinuclear region of cytoplasm]
GO:0061578 [Lys63-specific deubiquitinase activity]
GO:0070064 [proline-rich region binding]
GO:0070266 [necroptotic process]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0070536 [protein K63-linked deubiquitination]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097542 [ciliary tip]
GO:1902017 [regulation of cilium assembly]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001242 [regulation of intrinsic apoptotic signaling pathway]
Show all
 953 aa
107 kDa 		No 0
CYLD-002
ENSP00000462134
ENST00000566206
J3KRR7 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase CYLD
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0070266 [necroptotic process]
Show all
 910 aa
101.9 kDa 		No 0
CYLD-003
ENSP00000308928
ENST00000311559
Q9NQC7 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase CYLD
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005881 [cytoplasmic microtubule]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007049 [cell cycle]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008270 [zinc ion binding]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016055 [Wnt signaling pathway]
GO:0016579 [protein deubiquitination]
GO:0019901 [protein kinase binding]
GO:0030496 [midbody]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032480 [negative regulation of type I interferon production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0036064 [ciliary basal body]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0042347 [negative regulation of NF-kappaB import into nucleus]
GO:0045087 [innate immune response]
GO:0048471 [perinuclear region of cytoplasm]
GO:0061578 [Lys63-specific deubiquitinase activity]
GO:0070064 [proline-rich region binding]
GO:0070266 [necroptotic process]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0070536 [protein K63-linked deubiquitination]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097542 [ciliary tip]
GO:1902017 [regulation of cilium assembly]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001242 [regulation of intrinsic apoptotic signaling pathway]
Show all
 956 aa
107.3 kDa 		No 0
CYLD-005
ENSP00000381574
ENST00000398568
Q9NQC7 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase CYLD
A0A024R6T1 [Target identity:100%; Query identity:100%]
Cylindromatosis (Turban tumor syndrome), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005881 [cytoplasmic microtubule]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007049 [cell cycle]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008270 [zinc ion binding]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016055 [Wnt signaling pathway]
GO:0016579 [protein deubiquitination]
GO:0019901 [protein kinase binding]
GO:0030496 [midbody]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032480 [negative regulation of type I interferon production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0036064 [ciliary basal body]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0042347 [negative regulation of NF-kappaB import into nucleus]
GO:0045087 [innate immune response]
GO:0048471 [perinuclear region of cytoplasm]
GO:0061578 [Lys63-specific deubiquitinase activity]
GO:0070064 [proline-rich region binding]
GO:0070266 [necroptotic process]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0070536 [protein K63-linked deubiquitination]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097542 [ciliary tip]
GO:1902017 [regulation of cilium assembly]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001242 [regulation of intrinsic apoptotic signaling pathway]
Show all
 953 aa
107 kDa 		No 0
CYLD-006
ENSP00000454515
ENST00000564326
Q9NQC7 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase CYLD
A0A024R6T1 [Target identity:100%; Query identity:100%]
Cylindromatosis (Turban tumor syndrome), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005881 [cytoplasmic microtubule]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007049 [cell cycle]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008270 [zinc ion binding]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016055 [Wnt signaling pathway]
GO:0016579 [protein deubiquitination]
GO:0019901 [protein kinase binding]
GO:0030496 [midbody]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032480 [negative regulation of type I interferon production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0036064 [ciliary basal body]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0042347 [negative regulation of NF-kappaB import into nucleus]
GO:0045087 [innate immune response]
GO:0048471 [perinuclear region of cytoplasm]
GO:0061578 [Lys63-specific deubiquitinase activity]
GO:0070064 [proline-rich region binding]
GO:0070266 [necroptotic process]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0070536 [protein K63-linked deubiquitination]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097542 [ciliary tip]
GO:1902017 [regulation of cilium assembly]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001242 [regulation of intrinsic apoptotic signaling pathway]
Show all
 953 aa
107 kDa 		No 0
CYLD-007
ENSP00000456912
ENST00000566679
H3BSW9 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase CYLD
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0070266 [necroptotic process]
Show all
 304 aa
33.9 kDa 		No 0
CYLD-009
ENSP00000456488
ENST00000568704
H3BS09 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase CYLD
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0070266 [necroptotic process]
Show all
 771 aa
87.4 kDa 		No 0
CYLD-010
ENSP00000392025
ENST00000427738
Q9NQC7 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase CYLD
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005881 [cytoplasmic microtubule]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007049 [cell cycle]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008270 [zinc ion binding]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016055 [Wnt signaling pathway]
GO:0016579 [protein deubiquitination]
GO:0019901 [protein kinase binding]
GO:0030496 [midbody]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032480 [negative regulation of type I interferon production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0036064 [ciliary basal body]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0042347 [negative regulation of NF-kappaB import into nucleus]
GO:0045087 [innate immune response]
GO:0045581 [negative regulation of T cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0061578 [Lys63-specific deubiquitinase activity]
GO:0070064 [proline-rich region binding]
GO:0070266 [necroptotic process]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0070536 [protein K63-linked deubiquitination]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097542 [ciliary tip]
GO:1901026 [ripoptosome assembly involved in necroptotic process]
GO:1902017 [regulation of cilium assembly]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001242 [regulation of intrinsic apoptotic signaling pathway]
Show all
 956 aa
107.3 kDa 		No 0
CYLD-011
ENSP00000457108
ENST00000569681
H3BTB8 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase CYLD
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0070266 [necroptotic process]
Show all
 166 aa
18.9 kDa 		No 0
CYLD-012
ENSP00000455535
ENST00000564634
H3BPZ5 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase CYLD
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0070266 [necroptotic process]
Show all
 33 aa
4 kDa 		No 0
CYLD-014
ENSP00000458507
ENST00000566024
I3L117 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase CYLD
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0070266 [necroptotic process]
Show all
 66 aa
7.2 kDa 		No 0
CYLD-015
ENSP00000463197
ENST00000562884
J3QKR2 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase CYLD
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0070266 [necroptotic process]
Show all
 104 aa
11.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.