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SLC27A5

GENERAL INFORMATION

Gene name

 SLC27A5

Gene description

 Solute carrier family 27 (fatty acid transporter), member 5

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Mixed
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in hepatocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA007292 , CAB056160 , CAB068239
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007292
CAB056160
CAB068239

GENE INFORMATION

Gene name

 SLC27A5 (HGNC Symbol)

Synonyms

 ACSB, ACSVL6, FACVL3, FATP5, FLJ22987, VLACSR, VLCS-H2, VLCSH2

Description

 Solute carrier family 27 (fatty acid transporter), member 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.43

Chromosome location (bp)

 58479512 - 58512413

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000083807 (version 83.38)

Entrez gene

 10998

UniProt

 Q9Y2P5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2P5

Antibodypedia

 SLC27A5 antibodies

PROTEIN BROWSER
SLC27A5-001
SLC27A5-002
SLC27A5-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC27A5-001
ENSP00000263093
ENST00000263093
Q9Y2P5 [Direct mapping]
Bile acyl-CoA synthetase
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Enzymes
   ENZYME proteins
   Ligase
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000038 [very long-chain fatty acid metabolic process]
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005524 [ATP binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006642 [triglyceride mobilization]
GO:0006699 [bile acid biosynthetic process]
GO:0008152 [metabolic process]
GO:0008206 [bile acid metabolic process]
GO:0009925 [basal plasma membrane]
GO:0015245 [fatty acid transporter activity]
GO:0015721 [bile acid and bile salt transport]
GO:0015908 [fatty acid transport]
GO:0015911 [plasma membrane long-chain fatty acid transport]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0031957 [very long-chain fatty acid-CoA ligase activity]
GO:0032403 [protein complex binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0044281 [small molecule metabolic process]
GO:0046951 [ketone body biosynthetic process]
GO:0047747 [cholate-CoA ligase activity]
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 690 aa
75.4 kDa 		Yes 3
SLC27A5-002
ENSP00000470368
ENST00000601355
Q9Y2P5 [Direct mapping]
Bile acyl-CoA synthetase
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Enzymes
   ENZYME proteins
   Ligase
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000038 [very long-chain fatty acid metabolic process]
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005524 [ATP binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006699 [bile acid biosynthetic process]
GO:0008152 [metabolic process]
GO:0008206 [bile acid metabolic process]
GO:0015721 [bile acid and bile salt transport]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0031957 [very long-chain fatty acid-CoA ligase activity]
GO:0044281 [small molecule metabolic process]
GO:0047747 [cholate-CoA ligase activity]
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 606 aa
66.8 kDa 		Yes 4
SLC27A5-004
ENSP00000471065
ENST00000594786
M0R075 [Direct mapping]
Bile acyl-CoA synthetase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001676 [long-chain fatty acid metabolic process]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0006699 [bile acid biosynthetic process]
GO:0015245 [fatty acid transporter activity]
GO:0015908 [fatty acid transport]
GO:0016021 [integral component of membrane]
GO:0031957 [very long-chain fatty acid-CoA ligase activity]
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 95 aa
10.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.