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RPS5

GENERAL INFORMATION

Gene name

 RPS5

Gene description

 Ribosomal protein S5

Protein class

 Plasma proteins
Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA055878 , HPA061979
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA055878
HPA061979

GENE INFORMATION

Gene name

 RPS5 (HGNC Symbol)

Synonyms

 S5

Description

 Ribosomal protein S5 (HGNC Symbol)

Entrez gene summary

 Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.43

Chromosome location (bp)

 58386400 - 58394806

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000083845 (version 83.38)

Entrez gene

 6193

UniProt

 P46782 (UniProt - Evidence at protein level)

neXtProt

 NX_P46782

Antibodypedia

 RPS5 antibodies

PROTEIN BROWSER
RPS5-001
RPS5-002
RPS5-004
RPS5-005
RPS5-006
RPS5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPS5-001
ENSP00000470114
ENST00000601521
P46782 [Direct mapping]
40S ribosomal protein S5 40S ribosomal protein S5, N-terminally processed
A0A024R4Q8 [Target identity:100%; Query identity:100%]
Ribosomal protein S5, isoform CRA_a
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Ribosomal proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000028 [ribosomal small subunit assembly]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006450 [regulation of translational fidelity]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0015935 [small ribosomal subunit]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019843 [rRNA binding]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0030529 [ribonucleoprotein complex]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
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 204 aa
22.9 kDa 		No 0
RPS5-002
ENSP00000472985
ENST00000596046
P46782 [Direct mapping]
40S ribosomal protein S5 40S ribosomal protein S5, N-terminally processed
A0A024R4Q8 [Target identity:100%; Query identity:100%]
Ribosomal protein S5, isoform CRA_a
Show all
Ribosomal proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000028 [ribosomal small subunit assembly]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006450 [regulation of translational fidelity]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0015935 [small ribosomal subunit]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019843 [rRNA binding]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0030529 [ribonucleoprotein complex]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
Show all
 204 aa
22.9 kDa 		No 0
RPS5-004
ENSP00000471185
ENST00000596314
M0R0F0 [Direct mapping]
40S ribosomal protein S5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0006412 [translation]
GO:0015935 [small ribosomal subunit]
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 200 aa
22.4 kDa 		No 0
RPS5-005
ENSP00000470660
ENST00000598098
M0QZN2 [Direct mapping]
40S ribosomal protein S5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006412 [translation]
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 134 aa
14.8 kDa 		No 0
RPS5-006
ENSP00000471388
ENST00000598495
M0R0R2 [Direct mapping]
40S ribosomal protein S5
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0006412 [translation]
GO:0015935 [small ribosomal subunit]
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 225 aa
25.3 kDa 		No 0
RPS5-201
ENSP00000196551
ENST00000196551
P46782 [Direct mapping]
40S ribosomal protein S5 40S ribosomal protein S5, N-terminally processed
A0A024R4Q8 [Target identity:100%; Query identity:100%]
Ribosomal protein S5, isoform CRA_a
Show all
Ribosomal proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000028 [ribosomal small subunit assembly]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006450 [regulation of translational fidelity]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0015935 [small ribosomal subunit]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019843 [rRNA binding]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0030529 [ribonucleoprotein complex]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
Show all
 204 aa
22.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.