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PPIE

GENERAL INFORMATION

Gene name

 PPIE

Gene description

 Peptidylprolyl isomerase E (cyclophilin E)

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA020131
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA020131

GENE INFORMATION

Gene name

 PPIE (HGNC Symbol)

Synonyms

 CyP-33, MGC111222, MGC3736

Description

 Peptidylprolyl isomerase E (cyclophilin E) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]

Chromosome

 1

Cytoband

 p34.2

Chromosome location (bp)

 39692182 - 39763914

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000084072 (version 83.38)

Entrez gene

 10450

UniProt

 Q9UNP9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UNP9

Antibodypedia

 PPIE antibodies

PROTEIN BROWSER
PPIE-001
PPIE-002
PPIE-003
PPIE-006
PPIE-007
PPIE-008
PPIE-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPIE-001
ENSP00000312769
ENST00000324379
Q9UNP9 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase E
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Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006457 [protein folding]
GO:0016018 [cyclosporin A binding]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0071013 [catalytic step 2 spliceosome]
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 301 aa
33.4 kDa 		No 0
PPIE-002
ENSP00000348904
ENST00000356511
Q9UNP9 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase E
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006457 [protein folding]
GO:0016018 [cyclosporin A binding]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0071013 [catalytic step 2 spliceosome]
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 296 aa
33.1 kDa 		No 0
PPIE-003
ENSP00000361918
ENST00000372830
Q9UNP9 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase E
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006457 [protein folding]
GO:0016018 [cyclosporin A binding]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 314 aa
35 kDa 		No 0
PPIE-006
ENSP00000433475
ENST00000497370
E9PKY5 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0006457 [protein folding]
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 213 aa
23.8 kDa 		No 0
PPIE-007
ENSP00000361925
ENST00000372835
E9PEQ6 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003676 [nucleic acid binding]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0006457 [protein folding]
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 250 aa
27.7 kDa 		No 0
PPIE-008
ENSP00000436689
ENST00000470018
E9PIB0 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase E
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0006457 [protein folding]
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 72 aa
8.2 kDa 		No 0
PPIE-009
ENSP00000431714
ENST00000470213
E9PK21 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase E
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003676 [nucleic acid binding]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0006457 [protein folding]
Show all
 208 aa
22.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.