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Cancer tissues showed weak to moderate granular cytoplasmic positivity. Strong positivity was observed in several cases of lymphomas, testicular, colorectal and ovarian cancers. Renal cancers were generally negative.
Most cancer tissues showed weak to moderate nuclear positivity with additional cytoplasmic staining in a few cases. Several melanomas and basal cell carcinomas were negative.
GENE INFORMATION
Gene name
NOA1 (HGNC Symbol)
Synonyms
C4orf14, hAtNOS1, hNOA1, MGC3232, MTG3
Description
Nitric oxide associated 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a nuclear-encoded GTPase that functions in the mitochondrion. Upon translation, this protein is imported into the nucleus and then into the nucleolus before being exported to the mitochondrion. The encoded protein is required for oxygen-dependent regulation of mitochondrial respiratory complexes and for mitochondrial protein synthesis. [provided by RefSeq, Dec 2015]
Q8NC60 [Direct mapping] Nitric oxide-associated protein 1
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)