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Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]
P09211 [Direct mapping] Glutathione S-transferase P V9HWE9 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 22; Glutathione S-transferase pi, isoform CRA_b
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Enzymes ENZYME proteins Transferases THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000302 [response to reactive oxygen species] GO:0002674 [negative regulation of acute inflammatory response] GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006469 [negative regulation of protein kinase activity] GO:0006749 [glutathione metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007417 [central nervous system development] GO:0008144 [drug binding] GO:0008432 [JUN kinase binding] GO:0009636 [response to toxic substance] GO:0009890 [negative regulation of biosynthetic process] GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0014003 [oligodendrocyte development] GO:0019207 [kinase regulator activity] GO:0031100 [organ regeneration] GO:0031667 [response to nutrient levels] GO:0031982 [vesicle] GO:0032355 [response to estradiol] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0032869 [cellular response to insulin stimulus] GO:0032872 [regulation of stress-activated MAPK cascade] GO:0032873 [negative regulation of stress-activated MAPK cascade] GO:0032930 [positive regulation of superoxide anion generation] GO:0033591 [response to L-ascorbic acid] GO:0035726 [common myeloid progenitor cell proliferation] GO:0035730 [S-nitrosoglutathione binding] GO:0035731 [dinitrosyl-iron complex binding] GO:0035732 [nitric oxide storage] GO:0043066 [negative regulation of apoptotic process] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043200 [response to amino acid] GO:0043295 [glutathione binding] GO:0043407 [negative regulation of MAP kinase activity] GO:0043409 [negative regulation of MAPK cascade] GO:0043508 [negative regulation of JUN kinase activity] GO:0044281 [small molecule metabolic process] GO:0045471 [response to ethanol] GO:0046689 [response to mercury ion] GO:0048147 [negative regulation of fibroblast proliferation] GO:0051771 [negative regulation of nitric-oxide synthase biosynthetic process] GO:0070026 [nitric oxide binding] GO:0070062 [extracellular exosome] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:0070664 [negative regulation of leukocyte proliferation] GO:0071222 [cellular response to lipopolysaccharide] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0071385 [cellular response to glucocorticoid stimulus] GO:0071460 [cellular response to cell-matrix adhesion] GO:0071638 [negative regulation of monocyte chemotactic protein-1 production] GO:0097057 [TRAF2-GSTP1 complex] GO:1901687 [glutathione derivative biosynthetic process] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]