Cell atlas - APLP2 - The Human Protein Atlas

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APLP2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	APLP2
Gene description	Amyloid beta (A4) precursor-like protein 2
Protein class	Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA039319
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA039319	A-431	Vesicles
	HPA039319	U-2 OS	Vesicles
	HPA039319	U-251 MG	Vesicles

GENE INFORMATION
Gene name	APLP2 (HGNC Symbol)
Synonyms	APPH, APPL2
Description	Amyloid beta (A4) precursor-like protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Chromosome	11
Cytoband	q24.3
Chromosome location (bp)	130069837 - 130144811
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000084234 (version 83.38)
Entrez gene	334
UniProt	Q06481 (UniProt - Evidence at protein level)
neXtProt	NX_Q06481
Antibodypedia	APLP2 antibodies

PROTEIN BROWSER

APLP2-001	APLP2-002	APLP2-003	APLP2-005	APLP2-008	APLP2-011	APLP2-027

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APLP2-001 ENSP00000345444 ENST00000338167	Q06481 [Direct mapping] Amyloid-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008201 [heparin binding] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042802 [identical protein binding] GO:0046914 [transition metal ion binding] GO:0070062 [extracellular exosome] Show all	751 aa 85.5 kDa	Yes	1
APLP2-002 ENSP00000263575 ENST00000345598	Q06481 [Direct mapping] Amyloid-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008201 [heparin binding] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042802 [identical protein binding] GO:0046914 [transition metal ion binding] GO:0070062 [extracellular exosome] Show all	522 aa 59.2 kDa	Yes	1
APLP2-003 ENSP00000435914 ENST00000528499	Q06481 [Direct mapping] Amyloid-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008201 [heparin binding] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042802 [identical protein binding] GO:0046914 [transition metal ion binding] GO:0070062 [extracellular exosome] Show all	695 aa 79.2 kDa	Yes	1
APLP2-005 ENSP00000263574 ENST00000263574	Q06481 [Direct mapping] Amyloid-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001967 [suckling behavior] GO:0003677 [DNA binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0006878 [cellular copper ion homeostasis] GO:0007176 [regulation of epidermal growth factor-activated receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007617 [mating behavior] GO:0007626 [locomotory behavior] GO:0008201 [heparin binding] GO:0008203 [cholesterol metabolic process] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030198 [extracellular matrix organization] GO:0030900 [forebrain development] GO:0030901 [midbrain development] GO:0042802 [identical protein binding] GO:0043393 [regulation of protein binding] GO:0046914 [transition metal ion binding] GO:0050885 [neuromuscular process controlling balance] GO:0070062 [extracellular exosome] Show all	763 aa 87 kDa	Yes	1
APLP2-008 ENSP00000278756 ENST00000278756	Q06481 [Direct mapping] Amyloid-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008201 [heparin binding] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042802 [identical protein binding] GO:0046914 [transition metal ion binding] GO:0070062 [extracellular exosome] Show all	761 aa 87.2 kDa	No	1
APLP2-011 ENSP00000434059 ENST00000533195	E9PSC7 [Direct mapping] Amyloid-like protein 2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008201 [heparin binding] Show all	159 aa 17.3 kDa	Yes	0
APLP2-027 ENSP00000434379 ENST00000533713	E9PQS3 [Direct mapping] Amyloid-like protein 2 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008201 [heparin binding] GO:0046914 [transition metal ion binding] Show all	158 aa 17.8 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.