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NCOA1

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GENERAL INFORMATION

Gene name

 NCOA1

Gene description

 Nuclear receptor coactivator 1

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the plasma membrane & cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

Additional location

 In addition localized to the Plasma membrane (validated), Cytosol (validated)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by custom assay

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA070213 , HPA070520
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ASSAYS
RNA expression
Human cells
Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the plasma membrane & cytosol.

Main location

 Nucleoplasm (validated)

Additional location

 Plasma membrane (validated), Cytosol (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA070213 RH-30 Nucleoplasm Spatial
Cytosol Spatial
HPA070213 SiHa Nucleoplasm Spatial
Plasma membrane Spatial
Cytosol Spatial
HPA070213 U-2 OS Nucleoplasm
HPA070520 RH-30 Nucleoplasm Spatial
Cytosol Spatial
HPA070520 SiHa Nucleoplasm
HPA070520 U-2 OS Nucleoplasm Intensity Intensity
Plasma membrane Intensity Intensity
Cytosol Intensity Intensity

CUSTOM DATA

 

 

 
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Thumbnail

Antibody

Cell line

Assay

Description
HPA070520 U-2 OS Image Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. NCOA1 is mostly expressed during Mitosis.

CELL CYCLE

Summary

 Expression has cell cycle dependency according to custom assay

Intensity variation

 Plasma membrane

Spatial variation

 Cytosol, Nucleoplasm, Plasma membrane

GENE INFORMATION

Gene name

 NCOA1 (HGNC Symbol)

Synonyms

 bHLHe74, F-SRC-1, KAT13A, NCoA-1, RIP160, SRC1

Description

 Nuclear receptor coactivator 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p23.3

Chromosome location (bp)

 24491914 - 24770702

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000084676 (version 83.38)

Entrez gene

 8648

UniProt

 Q15788 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15788

Antibodypedia

 NCOA1 antibodies

PROTEIN BROWSER
NCOA1-001
NCOA1-002
NCOA1-003
NCOA1-009
NCOA1-201
NCOA1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NCOA1-001
ENSP00000385216
ENST00000406961
Q15788 [Direct mapping]
Nuclear receptor coactivator 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000435 [positive regulation of transcription from RNA polymerase II promoter by galactose]
GO:0000790 [nuclear chromatin]
GO:0001012 [RNA polymerase II regulatory region DNA binding]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0002155 [regulation of thyroid hormone mediated signaling pathway]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007595 [lactation]
GO:0008134 [transcription factor binding]
GO:0008206 [bile acid metabolic process]
GO:0008584 [male gonad development]
GO:0009725 [response to hormone]
GO:0015721 [bile acid and bile salt transport]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0019899 [enzyme binding]
GO:0021549 [cerebellum development]
GO:0021766 [hippocampus development]
GO:0021854 [hypothalamus development]
GO:0021987 [cerebral cortex development]
GO:0030331 [estrogen receptor binding]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030521 [androgen receptor signaling pathway]
GO:0032355 [response to estradiol]
GO:0032403 [protein complex binding]
GO:0032526 [response to retinoic acid]
GO:0032570 [response to progesterone]
GO:0032870 [cellular response to hormone stimulus]
GO:0033142 [progesterone receptor binding]
GO:0035257 [nuclear hormone receptor binding]
GO:0042974 [retinoic acid receptor binding]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043967 [histone H4 acetylation]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044849 [estrous cycle]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045925 [positive regulation of female receptivity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046965 [retinoid X receptor binding]
GO:0046983 [protein dimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0050681 [androgen receptor binding]
GO:0060179 [male mating behavior]
GO:0060713 [labyrinthine layer morphogenesis]
GO:1904017 [cellular response to Thyroglobulin triiodothyronine]
GO:2001038 [regulation of cellular response to drug]
GO:2001141 [regulation of RNA biosynthetic process]
Show all
 1441 aa
156.8 kDa 		No 0
NCOA1-002
ENSP00000385097
ENST00000405141
Q15788 [Direct mapping]
Nuclear receptor coactivator 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000435 [positive regulation of transcription from RNA polymerase II promoter by galactose]
GO:0000790 [nuclear chromatin]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008206 [bile acid metabolic process]
GO:0015721 [bile acid and bile salt transport]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0019899 [enzyme binding]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030521 [androgen receptor signaling pathway]
GO:0032870 [cellular response to hormone stimulus]
GO:0035257 [nuclear hormone receptor binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0050681 [androgen receptor binding]
Show all
 1399 aa
152.4 kDa 		No 0
NCOA1-003
ENSP00000379197
ENST00000395856
Q15788 [Direct mapping]
Nuclear receptor coactivator 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000435 [positive regulation of transcription from RNA polymerase II promoter by galactose]
GO:0000790 [nuclear chromatin]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008206 [bile acid metabolic process]
GO:0015721 [bile acid and bile salt transport]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0019899 [enzyme binding]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030521 [androgen receptor signaling pathway]
GO:0032870 [cellular response to hormone stimulus]
GO:0035257 [nuclear hormone receptor binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0050681 [androgen receptor binding]
Show all
 1440 aa
156.6 kDa 		No 0
NCOA1-009
ENSP00000385195
ENST00000407230
B5MCN7 [Direct mapping]
Nuclear receptor coactivator 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016573 [histone acetylation]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0032870 [cellular response to hormone stimulus]
GO:0035257 [nuclear hormone receptor binding]
Show all
 1248 aa
135.6 kDa 		No 0
NCOA1-201
ENSP00000288599
ENST00000288599
Q15788 [Direct mapping]
Nuclear receptor coactivator 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000435 [positive regulation of transcription from RNA polymerase II promoter by galactose]
GO:0000790 [nuclear chromatin]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008206 [bile acid metabolic process]
GO:0015721 [bile acid and bile salt transport]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0019899 [enzyme binding]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030521 [androgen receptor signaling pathway]
GO:0032870 [cellular response to hormone stimulus]
GO:0035257 [nuclear hormone receptor binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0050681 [androgen receptor binding]
Show all
 1399 aa
152.4 kDa 		No 0
NCOA1-202
ENSP00000320940
ENST00000348332
Q15788 [Direct mapping]
Nuclear receptor coactivator 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000435 [positive regulation of transcription from RNA polymerase II promoter by galactose]
GO:0000790 [nuclear chromatin]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008206 [bile acid metabolic process]
GO:0015721 [bile acid and bile salt transport]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0019899 [enzyme binding]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030521 [androgen receptor signaling pathway]
GO:0032870 [cellular response to hormone stimulus]
GO:0035257 [nuclear hormone receptor binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0050681 [androgen receptor binding]
Show all
 1441 aa
156.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.