Expression of AK6 in cancer - Summary - The Human Protein Atlas

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AK6

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AK6
Gene description	Adenylate kinase 6
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. CAB005361
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB005361

GENE INFORMATION
Gene name	AK6 (HGNC Symbol)
Synonyms	CINAP
Description	Adenylate kinase 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the adenylate kinase family of enzymes. The protein has a nuclear localization and contains Walker A (P-loop) and Walker B motifs and a metal-coordinating residue. The protein may be involved in regulation of Cajal body formation. In human, AK6 and TAF9 (GeneID: 6880) are two distinct genes that share 5' exons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Chromosome	5
Cytoband	q13.2
Chromosome location (bp)	69350984 - 69370013
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000085231 (version 83.38)
Entrez gene	102157402
UniProt	Q9Y3D8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y3D8
Antibodypedia	AK6 antibodies

PROTEIN BROWSER

AK6-001	AK6-004	AK6-010	AK6-011	AK6-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AK6-001 ENSP00000370201 ENST00000380822	Q9Y3D8 [Direct mapping] Adenylate kinase isoenzyme 6 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004017 [adenylate kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0015030 [Cajal body] GO:0016020 [membrane] GO:0016887 [ATPase activity] GO:0046939 [nucleotide phosphorylation] Show all	172 aa 20.1 kDa	No	0
AK6-004 ENSP00000370197 ENST00000380818	Q9Y3D8 [Direct mapping] Adenylate kinase isoenzyme 6 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004017 [adenylate kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0015030 [Cajal body] GO:0016020 [membrane] GO:0016887 [ATPase activity] GO:0046939 [nucleotide phosphorylation] Show all	169 aa 19.8 kDa	No	0
AK6-010 ENSP00000481620 ENST00000502819	A0A087WY94 [Direct mapping] Adenylate kinase isoenzyme 6; Transcription initiation factor TFIID subunit 9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		47 aa 5 kDa	No	0
AK6-011 ENSP00000420947 ENST00000512561	D6RDH4 [Direct mapping] Adenylate kinase isoenzyme 6; Transcription initiation factor TFIID subunit 9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		141 aa 16.9 kDa	No	0
AK6-012 ENSP00000479366 ENST00000618980	A0A087WVD7 [Direct mapping] Adenylate kinase isoenzyme 6; Transcription initiation factor TFIID subunit 9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		109 aa 12.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.