Expression of FCN1 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FCN1
Gene description	Ficolin (collagen/fibrinogen domain containing) 1
Protein class	Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (NB-4, U-937)
HPA (normal tissue):	Group enriched (appendix, bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in a subset of leukocytes, macrophages in lung, cells in spleen and bone marrow.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA000685 , HPA001295 , CAB016760
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA000685	HPA001295	CAB016760

GENE INFORMATION
Gene name	FCN1 (HGNC Symbol)
Synonyms	FCNM
Description	Ficolin (collagen/fibrinogen domain containing) 1 (HGNC Symbol)
Entrez gene summary	The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	134905890 - 134917963
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000085265 (version 83.38)
Entrez gene	2219
UniProt	O00602 (UniProt - Evidence at protein level)
neXtProt	NX_O00602
Antibodypedia	FCN1 antibodies

PROTEIN BROWSER

FCN1-001	FCN1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FCN1-001 ENSP00000360871 ENST00000371806	O00602 [Direct mapping] Ficolin-1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001664 [G-protein coupled receptor binding] GO:0001867 [complement activation, lectin pathway] GO:0002752 [cell surface pattern recognition receptor signaling pathway] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0006956 [complement activation] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008329 [signaling pattern recognition receptor activity] GO:0030246 [carbohydrate binding] GO:0031232 [extrinsic component of external side of plasma membrane] GO:0033691 [sialic acid binding] GO:0034394 [protein localization to cell surface] GO:0043654 [recognition of apoptotic cell] GO:0045087 [innate immune response] GO:0046597 [negative regulation of viral entry into host cell] GO:0046872 [metal ion binding] GO:2000484 [positive regulation of interleukin-8 secretion] Show all	326 aa 35.1 kDa	Yes	0
FCN1-201 ENSP00000479379 ENST00000616356	A0A087WVE2 [Direct mapping] Ficolin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		360 aa 39.2 kDa	Yes	1