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SEH1L

GENERAL INFORMATION

Gene name

 SEH1L

Gene description

 SEH1-like nucleoporin

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA039964
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SEH1L (HGNC Symbol)

Synonyms

 SEC13L, Seh1, SEH1A, SEH1B

Description

 SEH1-like nucleoporin (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is part of a nuclear pore complex, Nup107-160. This protein contains WD repeats and shares 34% amino acid identity with yeast Seh1 and 30% identity with yeast Sec13. All constituents of the Nup107-160 complex, including this protein, specifically localize to kinetochores in mitosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 18

Cytoband

 p11.21

Chromosome location (bp)

 12947133 - 12987536

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000085415 (version 83.38)

Entrez gene

 81929

UniProt

 Q96EE3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96EE3

Antibodypedia

 SEH1L antibodies

PROTEIN BROWSER
SEH1L-001
SEH1L-002
SEH1L-005
SEH1L-006
SEH1L-007
SEH1L-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SEH1L-001
ENSP00000262124
ENST00000262124
Q96EE3 [Direct mapping]
Nucleoporin SEH1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006999 [nuclear pore organization]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007080 [mitotic metaphase plate congression]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015031 [protein transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031080 [nuclear pore outer ring]
GO:0032008 [positive regulation of TOR signaling]
GO:0034198 [cellular response to amino acid starvation]
GO:0034605 [cellular response to heat]
GO:0034629 [cellular protein complex localization]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051028 [mRNA transport]
GO:0051301 [cell division]
GO:0051315 [attachment of mitotic spindle microtubules to kinetochore]
GO:0055085 [transmembrane transport]
GO:0061700 [GATOR2 complex]
GO:1900034 [regulation of cellular response to heat]
Show all
 360 aa
39.6 kDa 		No 0
SEH1L-002
ENSP00000382779
ENST00000399892
Q96EE3 [Direct mapping]
Nucleoporin SEH1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0002534 [cytokine production involved in inflammatory response]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006999 [nuclear pore organization]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007080 [mitotic metaphase plate congression]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015031 [protein transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031080 [nuclear pore outer ring]
GO:0032008 [positive regulation of TOR signaling]
GO:0034198 [cellular response to amino acid starvation]
GO:0034605 [cellular response to heat]
GO:0034629 [cellular protein complex localization]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051028 [mRNA transport]
GO:0051301 [cell division]
GO:0051315 [attachment of mitotic spindle microtubules to kinetochore]
GO:0055085 [transmembrane transport]
GO:0061700 [GATOR2 complex]
GO:1900034 [regulation of cellular response to heat]
Show all
 421 aa
46.6 kDa 		No 0
SEH1L-005
ENSP00000467605
ENST00000592170
K7EPZ5 [Direct mapping]
Nucleoporin SEH1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 77 aa
8.7 kDa 		No 0
SEH1L-006
ENSP00000467276
ENST00000589446
K7EP88 [Direct mapping]
Nucleoporin SEH1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 189 aa
21 kDa 		No 0
SEH1L-007
ENSP00000466959
ENST00000585730
K7ENI5 [Direct mapping]
Nucleoporin SEH1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 158 aa
17.6 kDa 		No 0
SEH1L-008
ENSP00000466234
ENST00000587761
K7ELV2 [Direct mapping]
Nucleoporin SEH1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 263 aa
29.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.