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OVGP1

GENERAL INFORMATION

Gene name

 OVGP1

Gene description

 Oviductal glycoprotein 1, 120kDa

Protein class

 Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (endometrial cancer, ovarian cancer)
HPA (cell line):Mixed
HPA (normal tissue):Tissue enriched (fallopian tube)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in fallopian tube.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA062205
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable) and endometrial cancer (favourable).
Urothelial cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (endometrial cancer, ovarian cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA062205

GENE INFORMATION

Gene name

 OVGP1 (HGNC Symbol)

Synonyms

 CHIT5, MUC9

Description

 Oviductal glycoprotein 1, 120kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p13.2

Chromosome location (bp)

 111414314 - 111427777

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000085465 (version 83.38)

Entrez gene

 5016

UniProt

 Q12889 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q12889

Antibodypedia

 OVGP1 antibodies

PROTEIN BROWSER
OVGP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OVGP1-001
ENSP00000358747
ENST00000369732
Q12889 [Direct mapping]
Oviduct-specific glycoprotein
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
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GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds]
GO:0004568 [chitinase activity]
GO:0005576 [extracellular region]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006032 [chitin catabolic process]
GO:0007338 [single fertilization]
GO:0007339 [binding of sperm to zona pellucida]
GO:0007565 [female pregnancy]
GO:0008061 [chitin binding]
GO:0030133 [transport vesicle]
GO:0032504 [multicellular organism reproduction]
GO:0035805 [egg coat]
GO:0098595 [perivitelline space]
GO:2000360 [negative regulation of binding of sperm to zona pellucida]
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 678 aa
75.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.