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SLC25A24

GENERAL INFORMATION

Gene name

 SLC25A24

Gene description

 Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic positivity with a granular mitochondrial pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA063636
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA063636

GENE INFORMATION

Gene name

 SLC25A24 (HGNC Symbol)

Synonyms

 APC1, DKFZp586G0123

Description

 Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 (HGNC Symbol)

Entrez gene summary

 This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

 1

Cytoband

 p13.3

Chromosome location (bp)

 108134036 - 108200849

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000085491 (version 83.38)

Entrez gene

 29957

UniProt

 Q6NUK1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6NUK1

Antibodypedia

 SLC25A24 antibodies

PROTEIN BROWSER
SLC25A24-001
SLC25A24-002
SLC25A24-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC25A24-001
ENSP00000457733
ENST00000565488
Q6NUK1 [Direct mapping]
Calcium-binding mitochondrial carrier protein SCaMC-1
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Transporters
   Electrochemical Potential-driven transporters
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005347 [ATP transmembrane transporter activity]
GO:0005509 [calcium ion binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006839 [mitochondrial transport]
GO:0010941 [regulation of cell death]
GO:0015867 [ATP transport]
GO:0016021 [integral component of membrane]
GO:0034599 [cellular response to oxidative stress]
GO:0055085 [transmembrane transport]
GO:0071277 [cellular response to calcium ion]
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 477 aa
53.4 kDa 		No 0
SLC25A24-002
ENSP00000359058
ENST00000370041
Q6NUK1 [Direct mapping]
Calcium-binding mitochondrial carrier protein SCaMC-1
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Transporters
   Electrochemical Potential-driven transporters
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005347 [ATP transmembrane transporter activity]
GO:0005509 [calcium ion binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006839 [mitochondrial transport]
GO:0010941 [regulation of cell death]
GO:0015867 [ATP transport]
GO:0016021 [integral component of membrane]
GO:0034599 [cellular response to oxidative stress]
GO:0055085 [transmembrane transport]
GO:0071277 [cellular response to calcium ion]
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 458 aa
51.4 kDa 		No 0
SLC25A24-004
ENSP00000454393
ENST00000569674
H3BMI3 [Direct mapping]
Calcium-binding mitochondrial carrier protein SCaMC-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
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 69 aa
7.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.