Expression of MAP3K4 in cancer - Summary - The Human Protein Atlas

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MAP3K4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MAP3K4
Gene description	Mitogen-activated protein kinase kinase kinase 4
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA007625
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007625

GENE INFORMATION
Gene name	MAP3K4 (HGNC Symbol)
Synonyms	KIAA0213, MAPKKK4, MEKK4, MTK1
Description	Mitogen-activated protein kinase kinase kinase 4 (HGNC Symbol)
Entrez gene summary	The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, May 2014]
Chromosome	6
Cytoband	q26
Chromosome location (bp)	160991727 - 161117385
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000085511 (version 83.38)
Entrez gene	4216
UniProt	Q9Y6R4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6R4
Antibodypedia	MAP3K4 antibodies

PROTEIN BROWSER

MAP3K4-001	MAP3K4-002	MAP3K4-006	MAP3K4-007	MAP3K4-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAP3K4-001 ENSP00000375986 ENST00000392142	Q9Y6R4 [Direct mapping] Mitogen-activated protein kinase kinase kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0000187 [activation of MAPK activity] GO:0001890 [placenta development] GO:0004672 [protein kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0010225 [response to UV-C] GO:0010468 [regulation of gene expression] GO:0019100 [male germ-line sex determination] GO:0035556 [intracellular signal transduction] GO:0043507 [positive regulation of JUN kinase activity] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0060718 [chorionic trophoblast cell differentiation] GO:1900745 [positive regulation of p38MAPK cascade] Show all	1608 aa 181.7 kDa	No	0
MAP3K4-002 ENSP00000355886 ENST00000366919	Q9Y6R4 [Direct mapping] Mitogen-activated protein kinase kinase kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0000187 [activation of MAPK activity] GO:0004672 [protein kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0010225 [response to UV-C] GO:0035556 [intracellular signal transduction] GO:0043507 [positive regulation of JUN kinase activity] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:1900745 [positive regulation of p38MAPK cascade] Show all	1558 aa 177 kDa	No	0
MAP3K4-006 ENSP00000355887 ENST00000366920	F5H538 [Direct mapping] Mitogen-activated protein kinase kinase kinase 4 Show all	MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000187 [activation of MAPK activity] GO:0004672 [protein kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] Show all	1604 aa 181.2 kDa	No	0
MAP3K4-007 ENSP00000297332 ENST00000348824	J3KNB8 [Direct mapping] Mitogen-activated protein kinase kinase kinase 4 Show all	MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000187 [activation of MAPK activity] GO:0004672 [protein kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] Show all	1554 aa 176.6 kDa	No	0
MAP3K4-010 ENSP00000390508 ENST00000448119	F5H534 [Direct mapping] Mitogen-activated protein kinase kinase kinase 4 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000187 [activation of MAPK activity] GO:0004708 [MAP kinase kinase activity] GO:0005622 [intracellular] Show all	23 aa 2.7 kDa	No	0

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