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CPNE3

GENERAL INFORMATION

Gene name

 CPNE3

Gene description

 Copine III

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA029552
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029552

GENE INFORMATION

Gene name

 CPNE3

Synonyms

Description

 Copine III (HGNC Symbol)

Entrez gene summary

 Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A domain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and extracellular ligands. [provided by RefSeq, Aug 2008]

Chromosome

 8

Cytoband

 q21.3

Chromosome location (bp)

 86484830 - 86561498

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000085719 (version 83.38)

Entrez gene

 8895

UniProt

 O75131 (UniProt - Evidence at protein level)

neXtProt

 NX_O75131

Antibodypedia

 CPNE3 antibodies

PROTEIN BROWSER
CPNE3-001
CPNE3-003
CPNE3-004
CPNE3-005
CPNE3-007
CPNE3-008
CPNE3-009
CPNE3-010
CPNE3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CPNE3-001
ENSP00000477590
ENST00000517490
O75131 [Direct mapping]
Copine-3
A0A024R994 [Target identity:100%; Query identity:100%]
Copine III, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0016192 [vesicle-mediated transport]
GO:0030054 [cell junction]
GO:0030335 [positive regulation of cell migration]
GO:0030971 [receptor tyrosine kinase binding]
GO:0038128 [ERBB2 signaling pathway]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0048306 [calcium-dependent protein binding]
GO:0070062 [extracellular exosome]
GO:0071277 [cellular response to calcium ion]
GO:0071363 [cellular response to growth factor stimulus]
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 537 aa
60.1 kDa 		No 0
CPNE3-003
ENSP00000482002
ENST00000621783
A0A087WYQ3 [Direct mapping]
Copine-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 234 aa
26.7 kDa 		No 0
CPNE3-004
ENSP00000478894
ENST00000620393
A0A087WUS8 [Direct mapping]
Copine-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 135 aa
15.1 kDa 		No 0
CPNE3-005
ENSP00000479670
ENST00000621526
A0A0G2JMP5 [Direct mapping]
Copine-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 9 aa
1 kDa 		No 0
CPNE3-007
ENSP00000481234
ENST00000621245
A0A087WXR6 [Direct mapping]
Copine-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 139 aa
15.6 kDa 		No 0
CPNE3-008
ENSP00000429561
ENST00000523469
E5RHZ0 [Direct mapping]
Copine-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 153 aa
17.3 kDa 		No 0
CPNE3-009
ENSP00000427966
ENST00000522240
E5RFT7 [Direct mapping]
Copine-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 79 aa
9 kDa 		No 0
CPNE3-010
ENSP00000428561
ENST00000517391
H0YB26 [Direct mapping]
Copine-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 262 aa
29.3 kDa 		No 0
CPNE3-201
ENSP00000198765
ENST00000198765
O75131 [Direct mapping]
Copine-3
A0A024R994 [Target identity:100%; Query identity:100%]
Copine III, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0016192 [vesicle-mediated transport]
GO:0030054 [cell junction]
GO:0030335 [positive regulation of cell migration]
GO:0030971 [receptor tyrosine kinase binding]
GO:0038128 [ERBB2 signaling pathway]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0048306 [calcium-dependent protein binding]
GO:0070062 [extracellular exosome]
GO:0071277 [cellular response to calcium ion]
GO:0071363 [cellular response to growth factor stimulus]
Show all
 537 aa
60.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.