Cell atlas - DDHD2 - The Human Protein Atlas

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DDHD2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Microtubule organizing center

Human cell
	Centrosome
	Cytosol

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GENERAL INFORMATION
Gene name	DDHD2
Gene description	DDHD domain containing 2
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the microtubule organizing center.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Additional location	In addition localized to the Microtubule organizing center (approved)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. CAB015202 , HPA023147
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the microtubule organizing center.

Main location

Cytosol (supported)

Additional location

Microtubule organizing center (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
CAB015202	A-431	Cytosol
CAB015202	U-251 MG	Cytosol
HPA023147	A-431	Microtubule organizing center
HPA023147	A-431	Cytosol
HPA023147	U-2 OS	Cytosol
HPA023147	U-251 MG	Microtubule organizing center
HPA023147	U-251 MG	Cytosol

GENE INFORMATION
Gene name	DDHD2 (HGNC Symbol)
Synonyms	KIAA0725, SAMWD1, SPG54
Description	DDHD domain containing 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a phospholipase enzyme containing sterile-alpha-motif (SAM), WWE, and DDHD domains. This protein participates in membrane trafficking between the endoplastic reticulum and the Golgi body. Mutations in this gene can cause autosomal recessive spastic paraplegia 54. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Chromosome	8
Cytoband	p11.23
Chromosome location (bp)	38225218 - 38275558
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000085788 (version 83.38)
Entrez gene	23259
UniProt	O94830 (UniProt - Evidence at protein level)
neXtProt	NX_O94830
Antibodypedia	DDHD2 antibodies

PROTEIN BROWSER

DDHD2-001	DDHD2-003	DDHD2-005	DDHD2-007	DDHD2-008	DDHD2-009	DDHD2-013	DDHD2-016	DDHD2-020	DDHD2-021	DDHD2-023	DDHD2-024

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDHD2-001 ENSP00000380352 ENST00000397166	O94830 [Direct mapping] Phospholipase DDHD2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0005794 [Golgi apparatus] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0016042 [lipid catabolic process] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] GO:0090141 [positive regulation of mitochondrial fission] Show all	711 aa 81 kDa	No	0
DDHD2-003 ENSP00000429932 ENST00000520272	O94830 [Direct mapping] Phospholipase DDHD2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0005794 [Golgi apparatus] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0016042 [lipid catabolic process] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] Show all	711 aa 81 kDa	No	0
DDHD2-005 ENSP00000429017 ENST00000517385	O94830 [Direct mapping] Phospholipase DDHD2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0005794 [Golgi apparatus] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0016042 [lipid catabolic process] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] Show all	330 aa 37.7 kDa	No	0
DDHD2-007 ENSP00000432433 ENST00000527834	E9PQY9 [Direct mapping] Phospholipase DDHD2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		156 aa 18 kDa	No	0
DDHD2-008 ENSP00000436444 ENST00000529642	E9PP45 [Direct mapping] Phospholipase DDHD2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		57 aa 7 kDa	No	0
DDHD2-009 ENSP00000433118 ENST00000528358	E9PM60 [Direct mapping] Phospholipase DDHD2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		161 aa 18.7 kDa	No	0
DDHD2-013 ENSP00000433578 ENST00000532222	E9PKE6 [Direct mapping] Phospholipase DDHD2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		222 aa 25.5 kDa	No	0
DDHD2-016 ENSP00000437097 ENST00000532106	H0YF30 [Direct mapping] Phospholipase DDHD2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		183 aa 20.4 kDa	No	0
DDHD2-020 ENSP00000435040 ENST00000528613	H0YE64 [Direct mapping] Phospholipase DDHD2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046872 [metal ion binding] Show all	79 aa 9.1 kDa	No	0
DDHD2-021 ENSP00000437029 ENST00000526144	H0YF17 [Direct mapping] Phospholipase DDHD2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046872 [metal ion binding] Show all	213 aa 24.4 kDa	No	0
DDHD2-023 ENSP00000432678 ENST00000533100	E9PPH8 [Direct mapping] Phospholipase DDHD2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		137 aa 15.7 kDa	No	0
DDHD2-024 ENSP00000431638 ENST00000529845	E9PK57 [Direct mapping] Phospholipase DDHD2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0046872 [metal ion binding] Show all	162 aa 18.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.