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DIMT1

GENERAL INFORMATION

Gene name

 DIMT1

Gene description

 DIM1 dimethyladenosine transferase 1 homolog

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA042944
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042944

GENE INFORMATION

Gene name

 DIMT1 (HGNC Symbol)

Synonyms

 DIMT1L, HSA9761

Description

 DIM1 dimethyladenosine transferase 1 homolog (HGNC Symbol)

Entrez gene summary

Chromosome

 5

Cytoband

 q12.1

Chromosome location (bp)

 62387254 - 62403939

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000086189 (version 83.38)

Entrez gene

 27292

UniProt

 Q9UNQ2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UNQ2

Antibodypedia

 DIMT1 antibodies

PROTEIN BROWSER
DIMT1-001
DIMT1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DIMT1-001
ENSP00000199320
ENST00000199320
Q9UNQ2 [Direct mapping]
Probable dimethyladenosine transferase
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000154 [rRNA modification]
GO:0000179 [rRNA (adenine-N6,N6-)-dimethyltransferase activity]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006364 [rRNA processing]
GO:0008649 [rRNA methyltransferase activity]
GO:0031167 [rRNA methylation]
GO:0044822 [poly(A) RNA binding]
GO:0052909 [18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity]
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 313 aa
35.2 kDa 		No 0
DIMT1-003
ENSP00000421754
ENST00000506390
A0A0C4DGB1 [Direct mapping]
Probable dimethyladenosine transferase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000154 [rRNA modification]
GO:0000179 [rRNA (adenine-N6,N6-)-dimethyltransferase activity]
GO:0006364 [rRNA processing]
GO:0008649 [rRNA methyltransferase activity]
GO:0031167 [rRNA methylation]
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 275 aa
30.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.