Expression of FOLH1 in cancer - Summary

GENERAL INFORMATION
Gene name	FOLH1
Gene description	Folate hydrolase (prostate-specific membrane antigen) 1
Protein class	Cancer-related genes Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (prostate cancer)
HPA (cell line):	Mixed
HPA (normal tissue):	Group enriched (duodenum, prostate, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in prostate, kidney tubules, duodenum and small intestine.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA010593 , CAB001451
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (favourable) and liver cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (prostate cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA010593	CAB001451

GENE INFORMATION
Gene name	FOLH1 (HGNC Symbol)
Synonyms	FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA
Description	Folate hydrolase (prostate-specific membrane antigen) 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
Chromosome	11
Cytoband	p11.12
Chromosome location (bp)	49146635 - 49208670
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000086205 (version 83.38)
Entrez gene	2346
UniProt	Q04609 (UniProt - Evidence at protein level)
neXtProt	NX_Q04609
Antibodypedia	FOLH1 antibodies

PROTEIN BROWSER

FOLH1-001	FOLH1-002	FOLH1-003	FOLH1-004	FOLH1-013	FOLH1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FOLH1-001 ENSP00000256999 ENST00000256999	Q04609 [Direct mapping] Glutamate carboxypeptidase 2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0006760 [folic acid-containing compound metabolic process] GO:0008233 [peptidase activity] GO:0008652 [cellular amino acid biosynthetic process] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016805 [dipeptidase activity] GO:0034641 [cellular nitrogen compound metabolic process] GO:0035609 [C-terminal protein deglutamylation] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:1904492 [Ac-Asp-Glu binding] GO:1904493 [tetrahydrofolyl-poly(glutamate) polymer binding] Show all	750 aa 84.3 kDa	No	1
FOLH1-002 ENSP00000349129 ENST00000356696	Q04609 [Direct mapping] Glutamate carboxypeptidase 2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008652 [cellular amino acid biosynthetic process] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0034641 [cellular nitrogen compound metabolic process] GO:0035609 [C-terminal protein deglutamylation] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:1904492 [Ac-Asp-Glu binding] GO:1904493 [tetrahydrofolyl-poly(glutamate) polymer binding] Show all	719 aa 80.6 kDa	No	1
FOLH1-003 ENSP00000344131 ENST00000340334	Q04609 [Direct mapping] Glutamate carboxypeptidase 2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008652 [cellular amino acid biosynthetic process] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0034641 [cellular nitrogen compound metabolic process] GO:0035609 [C-terminal protein deglutamylation] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:1904492 [Ac-Asp-Glu binding] GO:1904493 [tetrahydrofolyl-poly(glutamate) polymer binding] Show all	735 aa 82.5 kDa	No	0
FOLH1-004 ENSP00000431463 ENST00000533034	Q04609 [Direct mapping] Glutamate carboxypeptidase 2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008652 [cellular amino acid biosynthetic process] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0034641 [cellular nitrogen compound metabolic process] GO:0035609 [C-terminal protein deglutamylation] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:1904492 [Ac-Asp-Glu binding] GO:1904493 [tetrahydrofolyl-poly(glutamate) polymer binding] Show all	704 aa 78.8 kDa	No	0
FOLH1-013 ENSP00000431577 ENST00000529117	E9PKM3 [Direct mapping] Glutamate carboxypeptidase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		64 aa 7.5 kDa	No	0
FOLH1-201 ENSP00000344086 ENST00000343844	Q04609 [Direct mapping] Glutamate carboxypeptidase 2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008652 [cellular amino acid biosynthetic process] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0034641 [cellular nitrogen compound metabolic process] GO:0035609 [C-terminal protein deglutamylation] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:1904492 [Ac-Asp-Glu binding] GO:1904493 [tetrahydrofolyl-poly(glutamate) polymer binding] Show all	442 aa 50.1 kDa	No	0