Expression of EPDR1 in cancer - Summary - The Human Protein Atlas

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EPDR1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	EPDR1
Gene description	Ependymin related 1
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (WM-115)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. CAB026298
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable), stomach cancer (unfavourable) and liver cancer (unfavourable).
Urothelial cancer p<0.001 Stomach cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB026298

GENE INFORMATION
Gene name	EPDR1 (HGNC Symbol)
Synonyms	EPDR, MERP-1, MERP1, UCC1
Description	Ependymin related 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a type II transmembrane protein that is similar to two families of cell adhesion molecules, the protocadherins and ependymins. This protein may play a role in calcium-dependent cell adhesion. This protein is glycosylated, and the orthologous mouse protein is localized to the lysosome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Aug 2011]
Chromosome	7
Cytoband	p14.1
Chromosome location (bp)	37683843 - 37951941
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000086289 (version 83.38)
Entrez gene	54749
UniProt	Q9UM22 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UM22
Antibodypedia	EPDR1 antibodies

PROTEIN BROWSER

EPDR1-001	EPDR1-002	EPDR1-003	EPDR1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EPDR1-001 ENSP00000199448 ENST00000199448	Q9UM22 [Direct mapping] Mammalian ependymin-related protein 1 Show all	MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0005764 [lysosome] GO:0007160 [cell-matrix adhesion] GO:0070062 [extracellular exosome] Show all	224 aa 25.4 kDa	Yes	0
EPDR1-002 ENSP00000413359 ENST00000425345	Q9UM22 [Direct mapping] Mammalian ependymin-related protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0007160 [cell-matrix adhesion] GO:0070062 [extracellular exosome] Show all	163 aa 18.7 kDa	No	0
EPDR1-003 ENSP00000425858 ENST00000476620	D6RIH7 [Direct mapping] Mammalian ependymin-related protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0007160 [cell-matrix adhesion] Show all	122 aa 14.1 kDa	No	0
EPDR1-004 ENSP00000409211 ENST00000423717	Q9UM22 [Direct mapping] Mammalian ependymin-related protein 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0007160 [cell-matrix adhesion] GO:0070062 [extracellular exosome] Show all	90 aa 9.9 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.