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SNX10

GENERAL INFORMATION

Gene name

 SNX10

Gene description

 Sorting nexin 10

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Tissue enhanced (hypothalamus)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA015605
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SNX10

Synonyms

Description

 Sorting nexin 10 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

Chromosome

 7

Cytoband

 p15.2

Chromosome location (bp)

 26291895 - 26374329

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000086300 (version 83.38)

Entrez gene

 29887

UniProt

 Q9Y5X0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5X0

Antibodypedia

 SNX10 antibodies

PROTEIN BROWSER
SNX10-001
SNX10-002
SNX10-004
SNX10-005
SNX10-006
SNX10-007
SNX10-201
SNX10-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNX10-001
ENSP00000379661
ENST00000396376
Q9Y5X0 [Direct mapping]
Sorting nexin-10
A0A024RA70 [Target identity:100%; Query identity:100%]
Sorting nexin 10, isoform CRA_b
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005634 [nucleus]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005813 [centrosome]
GO:0006897 [endocytosis]
GO:0007032 [endosome organization]
GO:0015031 [protein transport]
GO:0016050 [vesicle organization]
GO:0030316 [osteoclast differentiation]
GO:0031313 [extrinsic component of endosome membrane]
GO:0035091 [phosphatidylinositol binding]
GO:0042384 [cilium assembly]
GO:0051117 [ATPase binding]
GO:0061512 [protein localization to cilium]
GO:0071539 [protein localization to centrosome]
Show all
 201 aa
23.6 kDa 		No 0
SNX10-002
ENSP00000343709
ENST00000338523
Q9Y5X0 [Direct mapping]
Sorting nexin-10
A0A024RA70 [Target identity:100%; Query identity:100%]
Sorting nexin 10, isoform CRA_b
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005634 [nucleus]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005813 [centrosome]
GO:0006897 [endocytosis]
GO:0007032 [endosome organization]
GO:0015031 [protein transport]
GO:0016050 [vesicle organization]
GO:0030316 [osteoclast differentiation]
GO:0031313 [extrinsic component of endosome membrane]
GO:0035091 [phosphatidylinositol binding]
GO:0042384 [cilium assembly]
GO:0051117 [ATPase binding]
GO:0061512 [protein localization to cilium]
GO:0071539 [protein localization to centrosome]
Show all
 201 aa
23.6 kDa 		No 0
SNX10-004
ENSP00000386540
ENST00000409838
Q9Y5X0 [Direct mapping]
Sorting nexin-10
Show all
Predicted intracellular proteins
Disease related genes
Show all
GO:0005515 [protein binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005634 [nucleus]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005813 [centrosome]
GO:0006897 [endocytosis]
GO:0007032 [endosome organization]
GO:0015031 [protein transport]
GO:0016050 [vesicle organization]
GO:0030316 [osteoclast differentiation]
GO:0031313 [extrinsic component of endosome membrane]
GO:0035091 [phosphatidylinositol binding]
GO:0042384 [cilium assembly]
GO:0051117 [ATPase binding]
GO:0061512 [protein localization to cilium]
GO:0071539 [protein localization to centrosome]
Show all
 117 aa
13.2 kDa 		No 0
SNX10-005
ENSP00000408164
ENST00000416246
C9JQ16 [Direct mapping]
Sorting nexin-10
Show all
Predicted intracellular proteins
Show all
GO:0005768 [endosome]
GO:0006897 [endocytosis]
GO:0016050 [vesicle organization]
GO:0035091 [phosphatidylinositol binding]
Show all
 197 aa
23.4 kDa 		No 0
SNX10-006
ENSP00000393690
ENST00000412416
C9JUQ6 [Direct mapping]
Sorting nexin-10
Show all
Predicted intracellular proteins
Show all
GO:0005768 [endosome]
GO:0006897 [endocytosis]
GO:0016050 [vesicle organization]
Show all
 53 aa
6.2 kDa 		No 0
SNX10-007
ENSP00000387274
ENST00000409367
G5E9H5 [Direct mapping]
Sorting nexin 10, isoform CRA_c; Sorting nexin-10
Show all
Predicted intracellular proteins
Show all
GO:0005768 [endosome]
GO:0006897 [endocytosis]
GO:0016050 [vesicle organization]
GO:0035091 [phosphatidylinositol binding]
Show all
 161 aa
18.6 kDa 		No 0
SNX10-201
ENSP00000395474
ENST00000446848
Q9Y5X0 [Direct mapping]
Sorting nexin-10
A0A024RA70 [Target identity:100%; Query identity:100%]
Sorting nexin 10, isoform CRA_b
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005634 [nucleus]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005813 [centrosome]
GO:0006897 [endocytosis]
GO:0007032 [endosome organization]
GO:0015031 [protein transport]
GO:0016050 [vesicle organization]
GO:0030316 [osteoclast differentiation]
GO:0031313 [extrinsic component of endosome membrane]
GO:0035091 [phosphatidylinositol binding]
GO:0042384 [cilium assembly]
GO:0051117 [ATPase binding]
GO:0061512 [protein localization to cilium]
GO:0071539 [protein localization to centrosome]
Show all
 201 aa
23.6 kDa 		No 0
SNX10-202
ENSP00000478710
ENST00000619420
A0A087WUJ3 [Direct mapping]
Sorting nexin-10
Show all
Predicted intracellular proteins
Show all
GO:0005768 [endosome]
GO:0006897 [endocytosis]
GO:0016050 [vesicle organization]
GO:0035091 [phosphatidylinositol binding]
Show all
 201 aa
23.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.