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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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TMED2
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

TMED2

Gene description

Transmembrane p24 trafficking protein 2

Protein class

Plasma proteins
Predicted membrane proteins
Predicted secreted proteins
Transporters

Predicted localization

Membrane,Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA014060
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable) and head and neck cancer (unfavourable).
Renal cancer p<0.001
Head and neck cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA014060

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant cells generally showed moderate cytoplasmic immunoreactivity. Hepatocellular carcinomas, several endometrial, breast and cervical adenocarcinomas were strongly stained. Many malignant lymphomas, skin and testicular cancers were weakly stained or negative.

GENE INFORMATION

Gene name

TMED2 (HGNC Symbol)

Synonyms

P24A, p24b1, p24beta1, RNP24

Description

Transmembrane p24 trafficking protein 2 (HGNC Symbol)

Entrez gene summary

Chromosome

12

Cytoband

q24.31

Chromosome location (bp)

123584531 - 123598577

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000086598 (version 83.38)

Entrez gene

10959

UniProt

Q15363 (UniProt - Evidence at protein level)

neXtProt

NX_Q15363

Antibodypedia

TMED2 antibodies

PROTEIN BROWSER

TMED2-001
TMED2-003
TMED2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TMED2-001
ENSP00000262225
ENST00000262225
Q15363 [Direct mapping]
Transmembrane emp24 domain-containing protein 2
Q6FHT8 [Target identity:100%; Query identity:100%]
RNP24 protein; Transmembrane emp24 domain trafficking protein 2, isoform CRA_a; cDNA, FLJ93436, Homo sapiens coated vesicle membrane protein (RNP24), mRNA
Show all
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001893 [maternal placenta development]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007030 [Golgi organization]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016021 [integral component of membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030137 [COPI-coated vesicle]
GO:0030663 [COPI-coated vesicle membrane]
GO:0032580 [Golgi cisterna membrane]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0034260 [negative regulation of GTPase activity]
GO:0035459 [cargo loading into vesicle]
GO:0042589 [zymogen granule membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048205 [COPI coating of Golgi vesicle]
GO:0048208 [COPII vesicle coating]
GO:0048598 [embryonic morphogenesis]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061024 [membrane organization]
GO:0072661 [protein targeting to plasma membrane]
Show all
201 aa
22.8 kDa
Yes 1
TMED2-003
ENSP00000405845
ENST00000438031
E7EQ72 [Direct mapping]
Transmembrane emp24 domain-containing protein 2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0016021 [integral component of membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
166 aa
18.5 kDa
Yes 0
TMED2-004
ENSP00000441161
ENST00000509052
F5GX39 [Direct mapping]
Transmembrane emp24 domain-containing protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0016021 [integral component of membrane]
Show all
116 aa
13.6 kDa
No 1

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