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TXLNG

GENERAL INFORMATION

Gene name

 TXLNG

Gene description

 Taxilin gamma

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, with cases of membrane expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA000297 , HPA000841
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA000297
HPA000841

GENE INFORMATION

Gene name

 TXLNG (HGNC Symbol)

Synonyms

 CXorf15, FIAT, FLJ11209, LSR5, MGC126621, MGC126625, TXLNGX

Description

 Taxilin gamma (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 16786427 - 16844519

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000086712 (version 83.38)

Entrez gene

 55787

UniProt

 Q9NUQ3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NUQ3

Antibodypedia

 TXLNG antibodies

PROTEIN BROWSER
TXLNG-001
TXLNG-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TXLNG-001
ENSP00000369465
ENST00000380122
Q9NUQ3 [Direct mapping]
Gamma-taxilin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007049 [cell cycle]
GO:0010564 [regulation of cell cycle process]
GO:0019905 [syntaxin binding]
GO:0030500 [regulation of bone mineralization]
GO:0031965 [nuclear membrane]
GO:0046982 [protein heterodimerization activity]
GO:0051726 [regulation of cell cycle]
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 528 aa
60.6 kDa 		No 0
TXLNG-201
ENSP00000381222
ENST00000398155
Q9NUQ3 [Direct mapping]
Gamma-taxilin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007049 [cell cycle]
GO:0010564 [regulation of cell cycle process]
GO:0019905 [syntaxin binding]
GO:0030500 [regulation of bone mineralization]
GO:0031965 [nuclear membrane]
GO:0046982 [protein heterodimerization activity]
GO:0051726 [regulation of cell cycle]
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 396 aa
46.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.