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HUWE1

GENERAL INFORMATION

Gene name

 HUWE1

Gene description

 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA002548 , CAB022718
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002548
CAB022718

GENE INFORMATION

Gene name

 HUWE1 (HGNC Symbol)

Synonyms

 Ib772, KIAA0312, UREB1

Description

 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation. [provided by RefSeq, Aug 2013]

Chromosome

 X

Cytoband

 p11.22

Chromosome location (bp)

 53532096 - 53686729

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000086758 (version 83.38)

Entrez gene

 10075

UniProt

 Q7Z6Z7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z6Z7

Antibodypedia

 HUWE1 antibodies

PROTEIN BROWSER
HUWE1-001
HUWE1-002
HUWE1-005
HUWE1-009
HUWE1-010
HUWE1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HUWE1-001
ENSP00000340648
ENST00000342160
Q7Z6Z7 [Direct mapping]
E3 ubiquitin-protein ligase HUWE1
A0A024R9W5 [Target identity:100%; Query identity:100%]
HECT, UBA and WWE domain containing 1, isoform CRA_b
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006284 [base-excision repair]
GO:0006513 [protein monoubiquitination]
GO:0016020 [membrane]
GO:0016574 [histone ubiquitination]
GO:0016874 [ligase activity]
GO:0030154 [cell differentiation]
GO:0044822 [poly(A) RNA binding]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 4374 aa
481.9 kDa 		No 1
HUWE1-002
ENSP00000479451
ENST00000612484
Q7Z6Z7 [Direct mapping]
E3 ubiquitin-protein ligase HUWE1
A0A024R9U8 [Target identity:100%; Query identity:100%]
HECT, UBA and WWE domain containing 1, isoform CRA_c
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006284 [base-excision repair]
GO:0006513 [protein monoubiquitination]
GO:0016020 [membrane]
GO:0016574 [histone ubiquitination]
GO:0016874 [ligase activity]
GO:0030154 [cell differentiation]
GO:0044822 [poly(A) RNA binding]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 4365 aa
481 kDa 		No 1
HUWE1-005
ENSP00000403236
ENST00000426907
H0Y659 [Direct mapping]
E3 ubiquitin-protein ligase HUWE1
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
Show all
 1197 aa
133.2 kDa 		No 0
HUWE1-009
ENSP00000484417
ENST00000622887
A0A087X1S3 [Direct mapping]
E3 ubiquitin-protein ligase HUWE1
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Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 230 aa
23.9 kDa 		No 0
HUWE1-010
ENSP00000413651
ENST00000446750
Q5H963 [Direct mapping]
E3 ubiquitin-protein ligase HUWE1; HECT, UBA and WWE domain containing 1
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Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 93 aa
10.9 kDa 		No 0
HUWE1-201
ENSP00000262854
ENST00000262854
Q7Z6Z7 [Direct mapping]
E3 ubiquitin-protein ligase HUWE1
A0A024R9W5 [Target identity:100%; Query identity:100%]
HECT, UBA and WWE domain containing 1, isoform CRA_b
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006284 [base-excision repair]
GO:0006513 [protein monoubiquitination]
GO:0016020 [membrane]
GO:0016574 [histone ubiquitination]
GO:0016874 [ligase activity]
GO:0030154 [cell differentiation]
GO:0044822 [poly(A) RNA binding]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 4374 aa
481.9 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.