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ACOX3

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GENERAL INFORMATION

Gene name

 ACOX3

Gene description

 Acyl-CoA oxidase 3, pristanoyl

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the peroxisome.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Peroxisomes (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA035840
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ASSAYS
RNA expression
Human cells
Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the peroxisome.

Main location

 Peroxisomes (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA035840 A-431 Peroxisomes
HPA035840 U-2 OS Peroxisomes
HPA035840 U-251 MG Peroxisomes

CUSTOM DATA

 

 

 
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Thumbnail

Antibody

Cell line

Assay

Description
HPA035840 U-2 OS Image ACOX3 localizes to peroxisomes, as it co-localizes with the peroxisomal marker ABCD3.

GENE INFORMATION

Gene name

 ACOX3

Synonyms

Description

 Acyl-CoA oxidase 3, pristanoyl (HGNC Symbol)

Entrez gene summary

 Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was undetectable by routine Northern-blot analysis or its product by immunoblotting or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p16.1

Chromosome location (bp)

 8366282 - 8440723

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000087008 (version 83.38)

Entrez gene

 8310

UniProt

 O15254 (UniProt - Evidence at protein level)

neXtProt

 NX_O15254

Antibodypedia

 ACOX3 antibodies

PROTEIN BROWSER
ACOX3-001
ACOX3-002
ACOX3-004
ACOX3-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACOX3-001
ENSP00000348775
ENST00000356406
O15254 [Direct mapping]
Peroxisomal acyl-coenzyme A oxidase 3
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0003997 [acyl-CoA oxidase activity]
GO:0005102 [receptor binding]
GO:0005739 [mitochondrion]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0006631 [fatty acid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0016020 [membrane]
GO:0016402 [pristanoyl-CoA oxidase activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase]
GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor]
GO:0055088 [lipid homeostasis]
GO:0055114 [oxidation-reduction process]
Show all
 700 aa
77.6 kDa 		No 0
ACOX3-002
ENSP00000413994
ENST00000413009
O15254 [Direct mapping]
Peroxisomal acyl-coenzyme A oxidase 3
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0003997 [acyl-CoA oxidase activity]
GO:0005102 [receptor binding]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0006631 [fatty acid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0016020 [membrane]
GO:0016402 [pristanoyl-CoA oxidase activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase]
GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor]
GO:0055088 [lipid homeostasis]
GO:0055114 [oxidation-reduction process]
Show all
 624 aa
69.6 kDa 		No 0
ACOX3-004
ENSP00000427321
ENST00000514423
D6RJ89 [Direct mapping]
Peroxisomal acyl-coenzyme A oxidase 3
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0008152 [metabolic process]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0055114 [oxidation-reduction process]
Show all
 110 aa
12.2 kDa 		No 0
ACOX3-005
ENSP00000421625
ENST00000503233
O15254 [Direct mapping]
Peroxisomal acyl-coenzyme A oxidase 3
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0003997 [acyl-CoA oxidase activity]
GO:0005102 [receptor binding]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0006631 [fatty acid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0016020 [membrane]
GO:0016402 [pristanoyl-CoA oxidase activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase]
GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor]
GO:0055088 [lipid homeostasis]
GO:0055114 [oxidation-reduction process]
Show all
 700 aa
77.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.