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HSD17B14

GENERAL INFORMATION

Gene name

 HSD17B14

Gene description

 Hydroxysteroid (17-beta) dehydrogenase 14

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (Karpas-707, RT4)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA021467
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and colorectal cancer (unfavourable).
Pancreatic cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021467

GENE INFORMATION

Gene name

 HSD17B14 (HGNC Symbol)

Synonyms

 DHRS10, retSDR3, SDR47C1

Description

 Hydroxysteroid (17-beta) dehydrogenase 14 (HGNC Symbol)

Entrez gene summary

 17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]).[supplied by OMIM, Jun 2009]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 48813017 - 48836678

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000087076 (version 83.38)

Entrez gene

 51171

UniProt

 Q9BPX1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BPX1

Antibodypedia

 HSD17B14 antibodies

PROTEIN BROWSER
HSD17B14-001
HSD17B14-002
HSD17B14-003
HSD17B14-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HSD17B14-001
ENSP00000263278
ENST00000263278
Q9BPX1 [Direct mapping]
17-beta-hydroxysteroid dehydrogenase 14
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0004303 [estradiol 17-beta-dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006706 [steroid catabolic process]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0047045 [testosterone 17-beta-dehydrogenase (NADP+) activity]
GO:0055114 [oxidation-reduction process]
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 270 aa
28.3 kDa 		No 0
HSD17B14-002
ENSP00000472746
ENST00000599157
M0R2R3 [Direct mapping]
17-beta-hydroxysteroid dehydrogenase 14
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   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 246 aa
25.6 kDa 		No 0
HSD17B14-003
ENSP00000469557
ENST00000595764
M0QY35 [Direct mapping]
17-beta-hydroxysteroid dehydrogenase 14
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 176 aa
19 kDa 		No 0
HSD17B14-004
ENSP00000471631
ENST00000596349
M0R147 [Direct mapping]
17-beta-hydroxysteroid dehydrogenase 14
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Predicted intracellular proteins
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GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 106 aa
11.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.