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ACHE

GENERAL INFORMATION

Gene name

 ACHE

Gene description

 Acetylcholinesterase (Yt blood group)

Protein class

 Blood group antigen proteins
Enzymes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (BEWO, CACO-2, K-562, Karpas-707)
HPA (normal tissue):Tissue enhanced (skeletal muscle)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and glioma (unfavourable).
Renal cancer p<0.001
Glioma p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 ACHE (HGNC Symbol)

Synonyms

 YT

Description

 Acetylcholinesterase (Yt blood group) (HGNC Symbol)

Entrez gene summary

 Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 100889994 - 100896974

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000087085 (version 83.38)

Entrez gene

 43

UniProt

 P22303 (UniProt - Evidence at protein level)

neXtProt

 NX_P22303

Antibodypedia

 ACHE antibodies

PROTEIN BROWSER
ACHE-001
ACHE-002
ACHE-003
ACHE-004
ACHE-006
ACHE-007
ACHE-008
ACHE-011
ACHE-013
ACHE-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACHE-001
ENSP00000241069
ENST00000241069
P22303 [Direct mapping]
Acetylcholinesterase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Blood group antigen proteins
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001507 [acetylcholine catabolic process in synaptic cleft]
GO:0001540 [beta-amyloid binding]
GO:0002076 [osteoblast development]
GO:0003990 [acetylcholinesterase activity]
GO:0004104 [cholinesterase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005605 [basal lamina]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006260 [DNA replication]
GO:0006581 [acetylcholine catabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0007155 [cell adhesion]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007416 [synapse assembly]
GO:0007517 [muscle organ development]
GO:0008283 [cell proliferation]
GO:0009611 [response to wounding]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0017171 [serine hydrolase activity]
GO:0030054 [cell junction]
GO:0031225 [anchored component of membrane]
GO:0031594 [neuromuscular junction]
GO:0032223 [negative regulation of synaptic transmission, cholinergic]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042166 [acetylcholine binding]
GO:0042803 [protein homodimerization activity]
GO:0042982 [amyloid precursor protein metabolic process]
GO:0043083 [synaptic cleft]
GO:0043236 [laminin binding]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050714 [positive regulation of protein secretion]
Show all
 614 aa
67.8 kDa 		Yes 0
ACHE-002
ENSP00000403474
ENST00000419336
P22303 [Direct mapping]
Acetylcholinesterase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Blood group antigen proteins
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001507 [acetylcholine catabolic process in synaptic cleft]
GO:0001540 [beta-amyloid binding]
GO:0002076 [osteoblast development]
GO:0003990 [acetylcholinesterase activity]
GO:0004104 [cholinesterase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005605 [basal lamina]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006260 [DNA replication]
GO:0006581 [acetylcholine catabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0007155 [cell adhesion]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007416 [synapse assembly]
GO:0007517 [muscle organ development]
GO:0008283 [cell proliferation]
GO:0009611 [response to wounding]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0017171 [serine hydrolase activity]
GO:0030054 [cell junction]
GO:0031225 [anchored component of membrane]
GO:0031594 [neuromuscular junction]
GO:0032223 [negative regulation of synaptic transmission, cholinergic]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042166 [acetylcholine binding]
GO:0042803 [protein homodimerization activity]
GO:0042982 [amyloid precursor protein metabolic process]
GO:0043083 [synaptic cleft]
GO:0043236 [laminin binding]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050714 [positive regulation of protein secretion]
Show all
 526 aa
58.4 kDa 		Yes 0
ACHE-003
ENSP00000404865
ENST00000411582
P22303 [Direct mapping]
Acetylcholinesterase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Blood group antigen proteins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001507 [acetylcholine catabolic process in synaptic cleft]
GO:0001540 [beta-amyloid binding]
GO:0002076 [osteoblast development]
GO:0003990 [acetylcholinesterase activity]
GO:0004104 [cholinesterase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005605 [basal lamina]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006260 [DNA replication]
GO:0006581 [acetylcholine catabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0007155 [cell adhesion]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007416 [synapse assembly]
GO:0007517 [muscle organ development]
GO:0008283 [cell proliferation]
GO:0009611 [response to wounding]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0017171 [serine hydrolase activity]
GO:0030054 [cell junction]
GO:0031225 [anchored component of membrane]
GO:0031594 [neuromuscular junction]
GO:0032223 [negative regulation of synaptic transmission, cholinergic]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042166 [acetylcholine binding]
GO:0042803 [protein homodimerization activity]
GO:0042982 [amyloid precursor protein metabolic process]
GO:0043083 [synaptic cleft]
GO:0043236 [laminin binding]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050714 [positive regulation of protein secretion]
Show all
 617 aa
67.4 kDa 		Yes 1
ACHE-004
ENSP00000400933
ENST00000445236
C9JUK5 [Direct mapping]
Acetylcholinesterase
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 28 aa
3 kDa 		No 0
ACHE-006
ENSP00000414858
ENST00000428317
P22303 [Direct mapping]
Acetylcholinesterase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Blood group antigen proteins
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001507 [acetylcholine catabolic process in synaptic cleft]
GO:0001540 [beta-amyloid binding]
GO:0002076 [osteoblast development]
GO:0003990 [acetylcholinesterase activity]
GO:0004104 [cholinesterase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005605 [basal lamina]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006260 [DNA replication]
GO:0006581 [acetylcholine catabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0007155 [cell adhesion]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007416 [synapse assembly]
GO:0007517 [muscle organ development]
GO:0008283 [cell proliferation]
GO:0009611 [response to wounding]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0017171 [serine hydrolase activity]
GO:0030054 [cell junction]
GO:0031225 [anchored component of membrane]
GO:0031594 [neuromuscular junction]
GO:0032223 [negative regulation of synaptic transmission, cholinergic]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042166 [acetylcholine binding]
GO:0042803 [protein homodimerization activity]
GO:0042982 [amyloid precursor protein metabolic process]
GO:0043083 [synaptic cleft]
GO:0043236 [laminin binding]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050714 [positive regulation of protein secretion]
Show all
 614 aa
67.8 kDa 		Yes 0
ACHE-007
ENSP00000396360
ENST00000441605
C9JD78 [Direct mapping]
Acetylcholinesterase
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004104 [cholinesterase activity]
GO:0008152 [metabolic process]
Show all
 159 aa
17.4 kDa 		Yes 0
ACHE-008
ENSP00000397143
ENST00000426415
C9J2S3 [Direct mapping]
Carboxylic ester hydrolase
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004104 [cholinesterase activity]
GO:0008152 [metabolic process]
Show all
 398 aa
42.6 kDa 		Yes 0
ACHE-011
ENSP00000399725
ENST00000430554
C9JZL6 [Direct mapping]
Carboxylic ester hydrolase
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004104 [cholinesterase activity]
GO:0008152 [metabolic process]
Show all
 435 aa
46.6 kDa 		Yes 0
ACHE-013
ENSP00000394976
ENST00000412389
P22303 [Direct mapping]
Acetylcholinesterase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Blood group antigen proteins
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001507 [acetylcholine catabolic process in synaptic cleft]
GO:0001540 [beta-amyloid binding]
GO:0002076 [osteoblast development]
GO:0003990 [acetylcholinesterase activity]
GO:0004104 [cholinesterase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005605 [basal lamina]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006260 [DNA replication]
GO:0006581 [acetylcholine catabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0007155 [cell adhesion]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007416 [synapse assembly]
GO:0007517 [muscle organ development]
GO:0008283 [cell proliferation]
GO:0009611 [response to wounding]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0017171 [serine hydrolase activity]
GO:0030054 [cell junction]
GO:0031225 [anchored component of membrane]
GO:0031594 [neuromuscular junction]
GO:0032223 [negative regulation of synaptic transmission, cholinergic]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042166 [acetylcholine binding]
GO:0042803 [protein homodimerization activity]
GO:0042982 [amyloid precursor protein metabolic process]
GO:0043083 [synaptic cleft]
GO:0043236 [laminin binding]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050714 [positive regulation of protein secretion]
Show all
 614 aa
67.8 kDa 		Yes 0
ACHE-201
ENSP00000303211
ENST00000302913
P22303 [Direct mapping]
Acetylcholinesterase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Blood group antigen proteins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001507 [acetylcholine catabolic process in synaptic cleft]
GO:0001540 [beta-amyloid binding]
GO:0001919 [regulation of receptor recycling]
GO:0002076 [osteoblast development]
GO:0003990 [acetylcholinesterase activity]
GO:0004104 [cholinesterase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005605 [basal lamina]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006260 [DNA replication]
GO:0006581 [acetylcholine catabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0007155 [cell adhesion]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007416 [synapse assembly]
GO:0007517 [muscle organ development]
GO:0008283 [cell proliferation]
GO:0009611 [response to wounding]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0017171 [serine hydrolase activity]
GO:0030054 [cell junction]
GO:0031225 [anchored component of membrane]
GO:0031594 [neuromuscular junction]
GO:0031623 [receptor internalization]
GO:0032223 [negative regulation of synaptic transmission, cholinergic]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042166 [acetylcholine binding]
GO:0042803 [protein homodimerization activity]
GO:0042982 [amyloid precursor protein metabolic process]
GO:0043083 [synaptic cleft]
GO:0043236 [laminin binding]
GO:0043621 [protein self-association]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0045212 [neurotransmitter receptor biosynthetic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050714 [positive regulation of protein secretion]
GO:0051262 [protein tetramerization]
GO:0060041 [retina development in camera-type eye]
Show all
 617 aa
67.4 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.