Expression of FTL in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FTL
Gene description	Ferritin, light polypeptide
Protein class	Cancer-related genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, highly abundant renal tubules, liver, adrenal gland and red pulp of spleen.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA041602 , CAB020769
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA041602	CAB020769

GENE INFORMATION
Gene name	FTL (HGNC Symbol)
Synonyms	MGC71996, NBIA3
Description	Ferritin, light polypeptide (HGNC Symbol)
Entrez gene summary	This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	48965301 - 48966878
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000087086 (version 83.38)
Entrez gene	2512
UniProt	P02792 (UniProt - Evidence at protein level)
neXtProt	NX_P02792
Antibodypedia	FTL antibodies

PROTEIN BROWSER

FTL-001	FTL-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FTL-001 ENSP00000366525 ENST00000331825	P02792 [Direct mapping] Ferritin light chain Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006826 [iron ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0006892 [post-Golgi vesicle-mediated transport] GO:0006898 [receptor-mediated endocytosis] GO:0008043 [intracellular ferritin complex] GO:0008199 [ferric iron binding] GO:0016020 [membrane] GO:0042802 [identical protein binding] GO:0055072 [iron ion homeostasis] GO:0055085 [transmembrane transport] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	175 aa 20 kDa	No	0
FTL-201 ENSP00000484043 ENST00000622577	A0A087X1B9 [Direct mapping] Ferritin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006826 [iron ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0008199 [ferric iron binding] Show all	190 aa 21.2 kDa	No	0