Most cancer tissues showed weak to moderate cytoplasmic positivity with additional nuclear staining in a few cases. A few cases of colorectal and breast cancers showed strong staining. Testicular and head & neck cancer were mainly negative.
ADAMTS2 (HGNC Symbol)
ADAM-TS2, ADAMTS-3, hPCPNI, NPI, PCINP
ADAM metallopeptidase with thrombospondin type 1 motif, 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene excises the N-propeptide of type I, type II and type V procollagens. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]