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CETP

GENERAL INFORMATION

Gene name

 CETP

Gene description

 Cholesteryl ester transfer protein, plasma

Protein class

 Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HEL, HUVEC TERT2, TIME)
HPA (normal tissue):Group enriched (adipose tissue, liver, lymph node, placenta, spleen)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CETP (HGNC Symbol)

Synonyms

 BPIFF

Description

 Cholesteryl ester transfer protein, plasma (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

Chromosome

 16

Cytoband

 q13

Chromosome location (bp)

 56961850 - 56983845

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000087237 (version 83.38)

Entrez gene

 1071

UniProt

 P11597 (UniProt - Evidence at protein level)

neXtProt

 NX_P11597

Antibodypedia

 CETP antibodies

PROTEIN BROWSER
CETP-001
CETP-002
CETP-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CETP-001
ENSP00000200676
ENST00000200676
P11597 [Direct mapping]
Cholesteryl ester transfer protein
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005319 [lipid transporter activity]
GO:0005548 [phospholipid transporter activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006641 [triglyceride metabolic process]
GO:0006869 [lipid transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0008203 [cholesterol metabolic process]
GO:0008289 [lipid binding]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010874 [regulation of cholesterol efflux]
GO:0015485 [cholesterol binding]
GO:0015914 [phospholipid transport]
GO:0017127 [cholesterol transporter activity]
GO:0017129 [triglyceride binding]
GO:0030301 [cholesterol transport]
GO:0031210 [phosphatidylcholine binding]
GO:0031982 [vesicle]
GO:0034197 [triglyceride transport]
GO:0034364 [high-density lipoprotein particle]
GO:0034372 [very-low-density lipoprotein particle remodeling]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0046470 [phosphatidylcholine metabolic process]
GO:0055088 [lipid homeostasis]
GO:0055091 [phospholipid homeostasis]
GO:0070062 [extracellular exosome]
GO:0070328 [triglyceride homeostasis]
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 493 aa
54.8 kDa 		Yes 0
CETP-002
ENSP00000369106
ENST00000379780
P11597 [Direct mapping]
Cholesteryl ester transfer protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005319 [lipid transporter activity]
GO:0005548 [phospholipid transporter activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006641 [triglyceride metabolic process]
GO:0006869 [lipid transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0008203 [cholesterol metabolic process]
GO:0008289 [lipid binding]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010874 [regulation of cholesterol efflux]
GO:0015485 [cholesterol binding]
GO:0015914 [phospholipid transport]
GO:0017127 [cholesterol transporter activity]
GO:0017129 [triglyceride binding]
GO:0030301 [cholesterol transport]
GO:0031210 [phosphatidylcholine binding]
GO:0031982 [vesicle]
GO:0034197 [triglyceride transport]
GO:0034364 [high-density lipoprotein particle]
GO:0034372 [very-low-density lipoprotein particle remodeling]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0046470 [phosphatidylcholine metabolic process]
GO:0055088 [lipid homeostasis]
GO:0055091 [phospholipid homeostasis]
GO:0070062 [extracellular exosome]
GO:0070328 [triglyceride homeostasis]
Show all
 433 aa
47.8 kDa 		Yes 0
CETP-003
ENSP00000456276
ENST00000566128
H3BRJ9 [Direct mapping]
Cholesteryl ester transfer protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008289 [lipid binding]
GO:0017127 [cholesterol transporter activity]
GO:0034364 [high-density lipoprotein particle]
GO:0043691 [reverse cholesterol transport]
Show all
 428 aa
48 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.